Inclusion Criteria:

- Age >21 years

- Postmenopausal status defined as cessation of menses for >1 year or FSH >20 mIU/mL

- History of stage I, II or IIIA hormone receptor-positive breast cancer, without
metastatic disease

- Currently taking a third-generation aromatase inhibitor for at least 3 months

- Clinical symptoms of knee and/or hand joint pain and/or stiffness for at least 3
months prior to study entry

- Ongoing musculoskeletal pain/stiffness in hand and/or knee joints (50 or higher on
the 100 point global assessment VAS) that started or increased since initiating
aromatase inhibitor therapy, and has been present for at least 3 months.

- patients must agree to refrain from use of glucosamine and chondroitin from sources
outside of this study

- If taking bisphosphonates, on a stable dose for at least 3 months and tolerating the
dose. Patients must agree to refrain from initiating bisphosphonate use during the
course of the study.

- ECOG performance status 0-2.

- Hemoglobin A1c <8.

- Signed informed consent

Exclusion Criteria:

- se of glucosamine or chondroitin within the past six months

- Concurrent medical/arthritic disease that could confound or interfere with evaluation
of pain or efficacy including:

- Inflammatory arthritis (e.g., rheumatoid arthritis, systemic lupus,
spondyloarthropathy, psoriatic arthritis, polymyalgia rheumatica)

- gout

- episodes of acute monarticular arthritis clinically consistent with pseudogout

- Paget's disease affecting the study joint

- a history of septic arthritis or avascular necrosis or intra-articular fracture
of the study joint

- Wilson's disease

- hemochromatosis

- alkaptonuria

- primary osteochondromatosis

- History of significant collateral ligament, anterior cruciate ligament or meniscal
injury of the index joint requiring surgery or non-weight bearing (requiring use of
crutches or cane) for more than 3 weeks (minor ligamentous injury prior to 6 months
is not an exclusion).

- History of bone fracture or surgery of the afflicted knees and/or hands within 6
months prior to study entry.

- AST, ALT > 2x normal.

- Serum Creatinine of > 1.8 mg/dl.

- Uncontrolled hypertension (Systolic Blood Pressure of > 150 mm Hg or Diastolic Blood
Pressure of >95 mm Hg).

- Uncontrolled diabetes mellitus, defined as Hemoglobin A1c level of > 8%.