Inclusion Criteria:

- Dated and signed informed concent

- Histologically or cytologically proven metastatic or locally advanced adenocarcinoma
of the exocrine pancreas (stadium UICC III/IV)

- Presence of at least one measurable (according to RECIST criteria) marker lesion
(primary tumor or metastasis) outside of an area that was previously subjected to
radiation therapy

- Failure of a palliative first line therapy of a metastatic or locally advanced
adenocarcinoma of the exocrine pancreas due to: Progress within 3 months after a
first-line therapy Discontinuation of a first-line therapy due to toxicity

- Age >= 18 years

- Karnofsky index > 60%

- Expected live span > 12 weeks

- Sufficient bone marrow reserve: Granulocytes >= 1.5 x 109/L and Platelets >= 100 x
109/L and Hemoglobin >= 9 g/L

- Serum Bilirubin < 2 x upper normal limit or 2.5 x upper normal limit in case of
hepatic metastasis (biliary drainage allowed)

- AST/ALT < 2.5 x upper normal limit

Exclusion Criteria:

- Every other cancer or secondary cancer besides the basal cell carcinoma of the skin
or the carcinoma in situ of the cervix uteri. Inclusion of patients with other types
of cancer that were successfully treated and that did not relapse within the last 5
years is possible

- Pregnancy or lactation

- Patients able to reproduce that do not adhere to strict contraception

- Presence of brain metastasis

- Severe, uncontrolled infection

- Preexisting peripheral neuropathy > grade I

- Preexisting severe illnesses such as unstable coronary artery disease or uncontrolled
cardiac arrhythmia

- Justified disbelief in the compliance of the patient

- Parallel participation in another clinical trial