Inclusion Criteria:

- Provide written informed consent prior to performance of any study procedures

- Is at least 18 years of age

- Have a diagnosis of advanced unresectable histologically confirmed HCC (excluding
fibrolamellar carcinoma)

- Have discontinued from first line treatment with sorafenib monotherapy for any reason
(ie, tumor disease progression, intolerance) at least 14 days prior to planned
randomization but have not received any second line treatment for HCC

- Have recovered from any significant sorafenib-related treatment toxicities prior to
randomization (Grade 1)

- Have at least 1 target lesion that is viable (has vascularization) and can be
accurately measured according to RECIST

- Patients who have received local therapy prior to sorafenib administration
(radiation, surgery, hepatic arterial embolization, chemoembolization, RFA,
percutaneous ethanol injection [PEI] or cryoablation) are eligible. Local therapy
must be completed at least 4 weeks prior to the baseline scan

- Have ECOG score of 0, 1, or 2

- Child-Pugh score <8

- Have adequate organ function defined as:

- Platelet count great than 50, less than 109/L;

- Hemoglobin 8.0 g/dL;

- Total bilirubin 3 mg/dL;

- Alanine transaminase (ALT) and aspartate aminotransferase (AST) less than or
equal to 5 X ULN;

- Serum creatinine 1.5 X ULN;

- PT-international normalized ratio (INR) 2.3 or PT 6 seconds above control

- Total white blood cell (WBC) count 2.0 109/L

- Is able to take medications orally (eg, no feeding tube)

- Women of childbearing potential must have a negative pregnancy test (urine or serum)
prior to randomization and within 2 days prior to starting the study drug. Females
must agree to adequate non-estrogenic birth control if conception is possible during
the study; and males must agree to adequate birth control during the study and up to
6 months after the discontinuation of study medication.

Exclusion Criteria:

- History of DVT, PE, myocardial infarction (MI), CVA, transitory ischemic attack
(TIA), or any other significant TE during the last 3 years

- Have clinically significant symptoms of hepatic encephalopathy or known brain
metastasis

- Patients who have had clinically significant acute gastrointestinal bleeding as a
result of portal vein hypertension within 4 weeks prior to randomization are
excluded; however, patients with a history of acute gastrointestinal bleeding that
have received appropriate treatment, ie, ligation of varices, are eligible

- Are receiving therapeutic regimens of anticoagulants, with the exception of
prophylaxis care of indwelling venous access devices

- Have received a liver transplant

- Are taking prohibited medication

- Have received a previous systemic therapy (including investigational agents) other
than sorafenib (see Inclusion Criterion 4) for treatment of HCC. Patients
participating in surveys or observational studies are eligible to participate in this
study

- Have had treatment with any of the following within the specified timeframe prior to
randomization:

- Any sorafenib within the 14 days prior to randomization

- Major surgery within the 4 weeks prior to randomization

- Any transfusion, treatment with blood component preparation, received
erythropoietin , albumin preparation, and granulocyte colony-stimulating factor
(G CSF) within the 2 weeks prior to randomization

- Has a serious illness or medical condition(s) including, but not limited to the
following:

- Known gastrointestinal disorder, including malabsorption, chronic nausea,
vomiting, or diarrhea present to the extent that it might interfere with oral
intake and absorption of the study medication

- Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome
(AIDS)-related illness

- Previous or concurrent malignancy except for basal cell carcinoma and/or in situ
carcinoma of the cervix, or other solid tumor treated curatively and without
evidence of recurrence for at least 3 years prior to the study

- Uncontrolled metabolic disorders or other nonmalignant organ or systemic
diseases or secondary effects of cancer that induce a high medical risk and/or
make assessment of survival uncertain

- Has active or uncontrolled clinically serious infection excluding chronic
hepatitis

- Other severe acute or chronic medical or psychiatric condition or laboratory
abnormality that may increase the risk associated with study participation or
study drug administration, or may interfere with the interpretation of study
results, and in the judgment of the Investigator would make the patient
inappropriate for entry into this study (eg, active urinary tract infection)

- Known allergy or hypersensitivity of TAC 101 and any other components used in
the TAC 101 tablet.