Inclusion Criteria:

- Male or female, >= 18 years of age.

- Histologically or cytologically confirmed malignant disease.

- Naive or non-naive to chemotherapy.

- Karnofsky index >= 70%.

- Scheduled to receive a single dose of at least one of the following agents
administered on Study Day 1: any dose of Dactynomicin, Carboplatin, Epirubicin,
Idarubicin, Ifosfamide, Irinotecan, Lomustine; or Methotrexate >250 mg/m^2, or
Cyclophosphamide <=1500 mg/m^2, or Mitoxantrone <15 mg/m^2, or Doxorubicin >= 20
mg/m^2, or Citarabin > 1g/m^2, Melphalan > 50 mg/m^2 , oxaliplatin > 75 mg/m^2
administered over 1 to 4 hours. The administration of the major chemotherapeutic
agent (which is the most emetogenic agent according to the classification of Hesketh,
et al., The Oncologist 1999, 4: 191-196) defined Study Day 1 and administration of
this agent should not extend beyond 4 hours.

- Provided signed written informed consent.

- Females of childbearing potential must be using reliable contraceptive measures with
a negative pregnancy test at the pre-treatment visit.

- If a patient had a known hepatic, renal or cardiovascular impairment and is scheduled
to receive the above mentioned chemotherapeutic agents, he/she could be enrolled in
this study at the discretion of the investigator.

- If a patient had experienced at maximum mild nausea following any previous
chemotherapy regimen, he/she could be enrolled in this study at the discretion of the
investigator.

Exclusion Criteria:

- Unable to understand or cooperate with the study procedures.

- Received any investigational drugs within 30 days before study entry.

- Received any drug with potential anti-emetic efficacy within 24 hours of the start of
treatment or will be scheduled to receive until Study Day 5 including 5-HT3 receptor
antagonists, metoclopramide, phenothiazine anti-emetics (including prochlorperazine,
thiethylperazine and perphenazine), scopolamine, diphenhydramine, chlorpheniramine
maleate, trimethobenzamide, all benzodiazepines except temazepam or triazolam used
once nightly for sleep, haloperidol, droperidol, tetrahydrocannabinol, or nabilone,
any corticosteroid including dexamethasone, hydrocortisone, methylprednisolone,
prednisone (excluding topical or inhaled preparations).

- Seizure disorder requiring anticonvulsant medication unless clinically stable and
free of seizure activity.

- Experienced any vomiting, retching, or NCI Common Toxicity Criteria grade 2 or 3
nausea in the 24 hours preceding chemotherapy.

- Ongoing vomiting from any organic etiology.

- Experienced nausea (moderate or severe) or vomiting following any previous
chemotherapy. At the discretion of the investigator, a patient who experienced at
maximum mild nausea following any previous chemotherapy might not be excluded from
this study.

- Scheduled to receive any dose of cisplatin, carmustine, hexametilamine, dacarbazine,
Mecloretamine, Streptozotocin, Procarbazine o Cyclophosphamide > 1500 mg/m^2 or any
other chemotherapeutic agent with an emetogenicity level 5 according to the
classification of NCCN Guidelines v1 2005 during Study Days 2-6.

- Known contraindication to 5-HT3 receptor antagonists.

- Scheduled to receive radiotherapy of the upper abdomen or cranium during Study Day
2-6.

- QTc > 500 msec at baseline.