Inclusion Criteria:

1. Subjects willing and able to give written informed consent

2. Confirmed metastatic castration resistant prostate cancer and rising PSA

3. ECOG performance status ≤ 1

4. Adequate renal function, hepatic function and bone marrow reserve.

5. Subjects capable of swallowing.

Exclusion Criteria:

1. Hypersensitivity to one or more of the Hamsa-1™ active components

2. Glucose-6-phosphate-dehydrogenase deficiency (G6PD)

3. Subjects with a clinically significant or unstable medical condition that would
preclude safe and complete study participation

4. Subjects who received any investigational medication, antineoplastic therapy, or any
significant change in treatment within 1 month prior to screening

5. Subjects with visceral metastases (e.g. liver, lung)

6. Subjects who received more than 2 prior chemotherapies for the treatment of prostate
cancer

7. Subjects suffering from circumstances likely to interfere with absorption of orally
administrated drugs

8. Subjects unwilling to or unable to comply with study protocol