Inclusion Criteria:

- Patients must be 18 years of age or older.

- Histological or cytological confirmation of malignant disease.

- Karnofsky index >= 50%

- Naïve to chemotherapy (First Cycle of chemotherapy IV with moderate or high emetic
risk administered during Day 1 of the study, according to modification of the
classification of Paul Hesketh's schema published on Annals of Oncology 17: 20-28,
2006 (Appendix 3).

- Patients that voluntarily sign the consent form.

Exclusion Criteria:

- Pregnancy or suspected.

- Patients during breast feeding.

- Inability to understand or cooperate with the study procedures.

- Received any investigational drugs within 30 days before study entry.

- Received any drug with potential anti-emetic efficacy within 24 hours prior to the
beginning of the treatment

- Seizure disorders requiring anticonvulsant medication.

- Persistent vomiting due to any organic etiology.

- Experienced any vomiting, nausea or retching, in the 24 hours prior to chemotherapy.

- Any systemic disease different to base disease

- Known current or history of drug or alcohol abuse

- Gastric outlet or intestinal obstruction