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Metabolic Effects of Androgenicity in Aging Men and Women


N/A
60 Years
85 Years
Open (Enrolling)
Male
Aging, Insulin Resistance

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Trial Information

Metabolic Effects of Androgenicity in Aging Men and Women


Inclusion Criteria:



- males age 60-85 years

- non-diabetic fasting glucose and 2-hour oral glucose tolerance test (OGTT)

- overall good general medical health and signed informed consent

- willing to travel to West LA VA and UCLA in Los Angeles, CA

Exclusion Criteria:

- any clinically significant abnormalities detected on screening physical exam or
laboratory testing (e.g. PSA > 4)

- or other symptom or history of a significant underlying medical or psychiatric
illness

- BMI < 20 or > 40

- subjects already on testosterone therapy or medications that might influence glucose
regulation or hormone levels

- subjects with a history of deep venous thromboses, pulmonary embolism, breast cancer,
prostate cancer, polycythemia or other contraindications to estrogen or testosterone

Type of Study:

Interventional

Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science

Outcome Measure:

Insulin Sensitivity

Outcome Time Frame:

6 weeks

Safety Issue:

No

Principal Investigator

Cathy Lee, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

VA Greater Los Angeles Healthcare System, West LA

Authority:

United States: Federal Government

Study ID:

ARCD-034-04F

NCT ID:

NCT00680797

Start Date:

January 2005

Completion Date:

June 2013

Related Keywords:

  • Aging
  • Insulin Resistance
  • Aging
  • Hormones
  • Insulin resistance
  • Insulin Resistance

Name

Location

VA Greater Los Angeles Healthcare System, West LAWest Los Angeles, California  90073