Inclusion Criteria:

- Biopsy-proven cancer verified at MSKCC

- Imaging evidence of lymph node metastases, bone metastases or soft tissue disease

- Age > or = to 18 years

- KPS > or = to 80

- Epidural disease is acceptable as long as the dose to the spinal cord ≤ 14 Gy

- Able to tolerate immobilization cradle positioning

Exclusion Criteria:

- Target lesion not visible on conventional CT scan

- Unable to be administered intravenous CT contrast safely

- Prior radiation to the planned target region. A second metastatic lesion would not be
eligible if the area received or will receive any dose (5% or greater isodose
line)from a prior or planned single fraction treatment

- Patients receiving concurrent chemotherapy (within 1 week of RT)

- Normal tissue directly overlying target precluding ability to limit the bowel,
bladder, rectum or other tissue to 15-16 Gy dose constraints

- Weight-bearing bones with significant cortical destruction from tumor. In these
cases, patients will be referred for orthopedic consultation for rod stabilization
procedures.

- Subjects with more than 4 metastases to bone

- Any metastatic lesion larger than 8 cm in its greatest diameter