Phase 2 Study of Tachikawa Project for Prevention of Posttraumatic Stress Disorder With Polyunsaturated Fatty Acid (TPOP): TPOP-01 Study
Accidental injuries, mostly motor vehicle accident, in civilian population are frequent
events. For instance, nearly one-third of injured patients appear to develop trauma-related
psychiatric illness and the major diagnoses are post-traumatic stress disorder (PTSD) and
depressive disorder. Omega-3 Polyunsaturated Fatty Acid (Omega-3 PUFA) has some evidence of
efficacy of treatment in patients with anxiety and mood disorders, but no evidence of
preventing anxiety and mood disorders that occur subsequent to accidental injuries. We
evaluate efficacy and safety of Omega-3 PUFA for the secondary prevention of Posttraumatic
Stress Disorder (PTSD) and related psychiatric illness in patients with accidental injury.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
Total score of Clinician-Administrated PTSD Scale (CAPS)
Yutaka Mastuoka, M.D., Ph.D.
National Disaster Medical Center, Tachikawa, Tokyo ,Japan
Japan: Institutional Review Board