Inclusion Criteria:

1. 18 plus years

2. A native Japanese speaking ability

3. Possibility contact patients with injury in 240 hours, and dosing in oral use

4. Physical and metal status to possible understands scope and contents in the trial and
gets informed consent

Exclusion Criteria:

1. Clearly irretrievable acute brain parenchyma damage and subdural or subarachnoidal
bleeding detected by computed tomography and/or magnetic resonance imaging

2. Cognitive impairment: Mini Mental State Examination < 24

3. Heavy drinker or 100IU/L ≦ γGTP in administration

4. Heavy smoker (over 40 cigarettes per day)

5. History and current suspicion in diagnosis of psychosis and bipolar I disorder

6. Suspicion in diagnosis of alcoholic, substance-related disorder and eating disorder

7. Existence of marked serious symptoms such as suicidal ideation, self-harm behavior,
dissociation, status of need rapidly psychiatric treatment

8. Use of anti-epilepsy drug, lithium, ethyl icosapentate and anti-coagulant drug (for
example, aspirin, warfarin, etc) within 3 month at regular intervals

9. Use of polyunsaturated fatty acid supplement within 3 month at regular intervals

10. Habit of eating fish over 4 times per week