Inclusion Criteria:

- Living in India for the duration of the study

- Adult females over age 18 years of age with a life expectancy of at least 3 months

- Confirmed breast cancer with evidence of locally advanced or metastatic disease

- Disease that is measurable by radiology imaging

- Ambulatory and capable of all selfcare but unable to carry out any work activities.

- Adequate laboratory results (hematologic, renal, hepatic)

- Negative pregnancy test

Exclusion Criteria:

- History of or susceptibility to bleeding or coagulopathy (e.g., von Willebrand
Disease or Hemophilia)

- Any history of thromboembolic events (clots within blood vessels)

- Ongoing treatment with high doses of anticoagulants

- Use of hormone therapy

- Advanced peripheral neuropathy (e.g., numbness, tingling, and/or pain in distal
extremities)

- Prior chemotherapy, immunotherapy or radiotherapy to an area of measurable disease
unless disease had recurred after radiotherapy

- Radiotherapy within 2 weeks entering the study

- Chemotherapy, immunotherapy or radiotherapy within 4 weeks of starting the study

- Allergies to Polysorbate 80 or drugs containing polyoxyethylated castor oil (e.g.
cyclosporine)

- Diagnosed and active CNS disease or metastatic lesions

- Major surgery within 4 weeks of starting the study

- Pregnant or nursing

- Uncontrolled disease (e.g., diabetes, hypertension, thyroid disease)

- History of heart disease

- History of any condition requiring treatment with anti-inflammatory, anti-platelet
drugs or steroids

- Diagnosed with HIV or hepatitis