Inclusion Criteria:

- Patients aged between 1 and 18 years at diagnosis with acute nonlymphocytic leukemia
in first remission are eligible for this protocol.

- Patients enrolled on the AML-87 study in second or subsequent remission are eligible
for this protocol.

Exclusion Criteria:

- Has an HLA-matched, MLC-compatible donor(unless parents and/or patient refuses
transplant.

- Diagnosis of FAB M3 or FAB M3v (acute progranulocytic leukemia)

- Life expectancy limited by disease other than leukemia

- Significant cardiac disease (echo shortening fraction <25% or MUGA scan <50%)

- Severe renal dysfunction, i.e., creatinine clearance less than 60cc/1.73 m2/min

- Severe restrictive pulmonary disease (FCV less than 40% of predicted)

- Severe hepatic disease (bilirubin greater than 3 mg/dl or SGPT greater than 500IU)

- Severe personality disorder or mental illness

- Previous severe cystitis from cyclophosphamide

- Previous total dose of anthracyclines of >450 mg/m2

- Sever infection that on evaluation by the PI precludes ablative chemotherapy or
successful transplantation

- Previous autologous transplant

- HIV reactivity

- Karnofsky score <70%