Inclusion Criteria

Inclusion Criteria

- Males and females of at least 18 years of age.

- Stage IIIB with pleural effusion or Stage IV non-squamous NSCLC.

- Measurable and/or evaluable disease according to RECIST.

- No prior chemotherapy, biological therapy or immunotherapy for Stage IIIB/IV disease.
Adjuvant therapy for early stage disease must have been completed > or = 6 months
prior to Cycle 1, Day 1 of this study.

- Eastern Cooperative Oncology Group (ECOG) performance status < or =1.

- A negative pregnancy test (serum or urine) in women of childbearing potential at
screening. Male subjects and female subjects of childbearing potential must be
willing to practice effective contraception during the study and be willing and able
to continue contraception for 6 months after the last dose of study drug.

- Ability to understand the purpose and risks of the study and provide signed and dated
informed consent and authorization to use protected health information (PHI) (in
accordance with national and local subject privacy regulations).

Exclusion Criteria

- Histological evidence of predominantly squamous cell carcinoma.

- Known central nervous system (CNS) metastases.

- Known allergy or sensitivity to murine proteins, chimeric antibodies or other
components of the product, Cremophor EL (polyoxyethylated castor oil), cisplatin, or
other platinum-containing compounds.

- Absolute neutrophil count (ANC) <1500/mm3, hemoglobin level <10 g/dL, or a platelet
count <100,000/mm3.

- Aspartate transaminase (AST), alanine transaminase (ALT), or alkaline phosphatase
values of .2.5 of the upper limits of normal values (ULN) (>5 ULN for subjects with
liver metastases) or alkaline phosphatase values >2.5 ULN (unless documented bone
metastases are responsible for the increase of alkaline phosphatase); total bilirubin
>1.5 mg/dL, or serum creatinine >1.8 mg/dL.

- Radiation therapy within 1 month before Cycle 1, Day 1.

- Documented symptomatic central nervous system (CNS) tumor or CNS metastases.

- History of thromboembolic events, including cardiovascular or cerebrovascular events
(ie, acute myocardial infarction [AMI], stroke) within 1 year prior to Cycle 1, Day
1.

- History of known bleeding disorders and coagulation defects.

- History of significant hemoptysis (ie, > or = 1/2 teaspoon red blood per event) or
gastrointestinal bleeding within 1 year prior to Cycle 1, Day 1.

- Major surgery (eg, exploratory laparotomy) within 4 weeks prior to Cycle 1, Day 1 of
the study.

- Clinically significant or unstable medical conditions including, but not limited to,
uncontrolled diabetes mellitus requiring insulin, uncontrolled hypertension, or
uncontrolled or symptomatic orthostatic hypotension.

- Oxygen-dependent chronic obstructive pulmonary disease.

- Known active infections requiring intravenous (IV) antibiotics, antivirals, or
antifungals, including but not limited to chronic human immunodeficiency virus,
hepatitis B, or hepatitis C infection.

- Prior bone marrow or stem cell transplant.

- Regular use of aspirin, nonsteroidal anti-inflammatory agents, or other agents known
to inhibit platelet function.

- High-dose warfarin or heparin use. [Note: Low-dose warfarin (1 mg/day) or low-dose
heparin for IV-catheter patency, and low-molecular weight heparin for prophylaxis are
allowed).