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An Investigation of Eight Reported Cases of Small Intestinal Carcinoid Carcinoma in Multiple Family Members

12 Years
Open (Enrolling)
Carcinoid Carcinoma

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Trial Information

An Investigation of Eight Reported Cases of Small Intestinal Carcinoid Carcinoma in Multiple Family Members

There have not been any studies published which specifically describe the medical,
environmental, and genetic factors in carcinoid tumors cases that have carcinoid in family
members. While rare, with an incidence of four per 100, 000, carcinoid represents the most
frequent malignancy affecting the small intestine. Because nearly half (49%) of the cases of
gastrointestinal carcinoid tumors have hepatic metastasis at diagnosis, identification of
the risk factors associated with carcinoid has the potential to increase early diagnosis and
cure. Carcinoid tumors are thought to occur spontaneously and not associated with an
inherited genetic abnormality that would increase a family member's risk for developing
carcinoid cancer. There is a known inherited genetic abnormality that is associated with
bronchial carcinoid tumors but only less than 10%. Gastrointestinal carcinoid tumors are
not thought to be associated with a inherited genetic abnormality. There have been several
small studies that have examined gastrointestinal carcinoid in multiple family members. It
remains uncertain if these cases of carcinoid in multiple family members are characteristic
of a heritable or environmental etiology. Most carcinoid cancer is not inherited; however,
less than 10% of neuroendocrine carcinoid cancer is thought to be due to a change (called a
"mutation") in a gene inherited from a parent. There are several genes that are suspected to
be associated with carcinoid cancer, two of interest in this study is the Multiple Endocrine
Neoplasia Type1 (MEN1), and succinate dehydrogenase complex, subunit D (SDHD) genes.

Inclusion Criteria:

1. Over the age of 18 years

2. History of biopsy confirmed small intestinal carcinoid tumor

3. English speaking

4. Mentally and emotionally capable of answering questions

5. Willing and available for study participation

6. At least one first-degree family member with carcinoid tumor

Exclusion Criteria:

1. If you are under the age of 18 years,

2. If you have any mental or memory impairments

3. If you are unable to understand the information in the informed consent document.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Retrospective

Outcome Measure:

identification of carcinoid in multiple family members

Outcome Time Frame:

lifetime history

Safety Issue:


Principal Investigator

Nancy Gardner, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Rutgers University


United States: Institutional Review Board

Study ID:




Start Date:

January 2008

Completion Date:

November 2008

Related Keywords:

  • Carcinoid Carcinoma
  • carcinoid
  • familial
  • Collect and describe information about the medical and environmental factors associated with each cases of carcinoid carcinoma
  • Develop a genogram representing the family cancer history of cases of Carcinoid.
  • Carcinoid Tumor
  • Carcinoma



Rutgers University College of Nursing Newark, New Jersey  07102