An Investigation of Eight Reported Cases of Small Intestinal Carcinoid Carcinoma in Multiple Family Members
There have not been any studies published which specifically describe the medical,
environmental, and genetic factors in carcinoid tumors cases that have carcinoid in family
members. While rare, with an incidence of four per 100, 000, carcinoid represents the most
frequent malignancy affecting the small intestine. Because nearly half (49%) of the cases of
gastrointestinal carcinoid tumors have hepatic metastasis at diagnosis, identification of
the risk factors associated with carcinoid has the potential to increase early diagnosis and
cure. Carcinoid tumors are thought to occur spontaneously and not associated with an
inherited genetic abnormality that would increase a family member's risk for developing
carcinoid cancer. There is a known inherited genetic abnormality that is associated with
bronchial carcinoid tumors but only less than 10%. Gastrointestinal carcinoid tumors are
not thought to be associated with a inherited genetic abnormality. There have been several
small studies that have examined gastrointestinal carcinoid in multiple family members. It
remains uncertain if these cases of carcinoid in multiple family members are characteristic
of a heritable or environmental etiology. Most carcinoid cancer is not inherited; however,
less than 10% of neuroendocrine carcinoid cancer is thought to be due to a change (called a
"mutation") in a gene inherited from a parent. There are several genes that are suspected to
be associated with carcinoid cancer, two of interest in this study is the Multiple Endocrine
Neoplasia Type1 (MEN1), and succinate dehydrogenase complex, subunit D (SDHD) genes.
Observational
Observational Model: Case-Only, Time Perspective: Retrospective
identification of carcinoid in multiple family members
lifetime history
No
Nancy Gardner, PhD
Principal Investigator
Rutgers University
United States: Institutional Review Board
08-151
NCT00662168
January 2008
November 2008
Name | Location |
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Rutgers University College of Nursing | Newark, New Jersey 07102 |