Inclusion Criteria:

- Metastatic uveal melanoma in the liver with histological confirmation

- Ability/willingness to give informed consent

- ECOG performance status of 0 or 1

- Adequate renal, liver and bone marrow function

Exclusion Criteria:

- Solitary liver metastasis that is amenable to surgical removal

- Presence of symptomatic liver failure including ascites and hepatic
encephalopathy

- Presence of extra-hepatic metastases

- Untreated brain metastases

- Uncontrolled hypertension or congestive heart failure or acute myocardial infarction
within 6 months of entry

- Presence of any other medical complication that imply survival of less than six
months

- Uncontrolled sever bleeding tendency or active GI bleeding

- Significant allergic reaction to contrast dye or GM-CSF

- Immunosuppressive treatments such as systemic steroids, radiation to pelvis or
systemic chemotherapy within 4 weeks

- Previous embolization of the hepatic artery or intrahepatic arterial chemotherapy of
liver metastasis

- Active hepatitis with SGOT and SGPT greater than 5 x normal

- HIV infection positive by ELISA

- Pregnancy or breast feeding women

- Biliary obstruction, biliary stent or prior biliary surgery except cholecystectomy

- Significant arteriovenous shunt identified on angiography of the hepatic artery

- Occlusion of main portal vein or inadequate collateral flow around an occluded portal
vein