Inclusion Criteria:

- Subjects must be 18 years old.

- Must have a confirmed diagnosis of solid tumor that has been refractory to prior
therapy and for which no additional therapy of known benefit is available.

- Must have measurable or non-measurable disease as defined by RECIST guidelines.

- Be male or non-pregnant, non-lactating female. A negative pregnancy test within one
week prior to the start of the study if a female of childbearing potential.

- Subjects and their partners with reproductive potential must agree to use an
effective contraceptive method (as deemed by the Investigator) while the subject is
on study treatment and for 30 days after the last treatment.

- Must have a life expectancy of at least 3 months.

- Must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or
2

- Must not be receiving any concurrent anticancer therapy.

- At least 4 weeks must have elapsed between any prior systemic treatment for the
cancer (6 weeks for mitomycin and nitrosourea) and first dose of treatment on this
protocol; at least 4 weeks must have elapsed between any prior radiation treatment
for the cancer or major surgical procedure and the first dose of treatment on this
protocol; all acute and chronic toxicities from prior treatment must have recovered
to ≤ grade 1. Subjects with prostate cancer on Lupron® will be allowed to continue
their treatment.

- Must have physical integrity of the gastrointestinal tract.

- Must have adequate organ and immune function as indicated by the following laboratory
values:

- Serum creatinine <1.5 x ULN or

- Estimated creatinine clearance >45mL/min,

- Total Bilirubin <2.0mg/dL (<34.2umol/L),

- AST (SGOT) & ALT (SGPT) <3 x ULN,

- Lymphocytes >LLN,

- White Blood Cells >3.2 x 10^9cells/L,

- Absolute Granulocyte Count >1.5 x 10^9cells/L,

- HG >9g/dl without transfusion,

- Platelets >100,000/µl.

- Must understand, be able, willing and likely to fully comply with study procedures,
including scheduled follow-up, and restrictions.

- The subject must give written signed and dated informed consent to participate in the
study, in accordance with the International Conference on Harmonization (ICH) Good
Clinical Practice (GCP) Guidelines, before completing any study related procedures.

Exclusion Criteria:

- Clinical evidence of active CNS involvement by malignancy. Subjects whose brain
metastases were treated with radiation more than 8 weeks prior to entry on the trial,
off steroids for at least 4 weeks, and with no evidence of disease progression in the
brain for a minimum of 8 weeks are eligible for the trial.

- Active and uncontrolled infection.

- Hematologic cancers.

- Any uncontrolled medical problems, unrelated to the malignancy, or of sufficient
severity that in the opinion of the Investigator, impair a subject's ability to give
informed consent or unacceptably reduce the safety of the proposed treatment.

- Neurological or psychiatric disorders that would interfere with consent or study
follow-up.

- Known or suspected intolerance or hypersensitivity to the study materials or closely
related compounds] or any of their stated ingredients.

- History of alcohol or other substance abuse within the last year.

- Concurrent use of steroids or other immune suppressive agent.

- Known positive test for HIV.

- Evidence of bowel obstruction because of the theoretical possibility of GI
perforation with an anti-angiogenesis agent.

- Female subjects who are pregnant or lactating.

- Subjects who have previously been enrolled into this study and subsequently
withdrawn.