Inclusion Criteria:

- Histological or cytological diagnosis of non-small cell carcinoma of the lung

- Initially stage III NSCLC

- Pathologically proven N2 or N3 disease

- Any response to induction chemotherapy (whatever the regimen administered)

- Disease still not fully resectable (because of extensive mediastinal N disease) and
not suitable for radical radiotherapy (single field) after induction chemotherapy

- Lobectomy possible for the treatment of T disease

- Availability for participating in the detailed follow-up of the protocol

- Informed consent

Exclusion Criteria:

- Prior treatment with radiotherapy or surgery

- Karnofsky PS < 60

- Functional or anatomical contra-indication to mediastinal radiotherapy

- Functional or anatomical contra-indication to surgical lobectomy

- A history of prior malignant tumour, except non-melanoma skin cancer or in situ
carcinoma of the cervix or cured malignant tumour (more than 5 year disease-free
interval)

- Malignant pleural or pericardial effusion

- Neutrophils < 2,000/mm³

- Platelet cells < 100,000/mm3

- Serum bilirubin > 1.5 mg/100 ml

- Serum creatinine > 1.5 mg/100 ml and/or creatinine clearance < 60 ml/min

- Recent myocardial infarction (less than 3 months prior to date of diagnosis)

- Congestive cardiac failure or cardiac arrhythmia requiring medical treatment

- Uncontrolled infectious disease

- Hearing loss

- Symptomatic polyneuropathy

- Serious medical or psychological factors which may prevent adherence to the treatment
schedule