HLA Class I Haplotype Mismatched Natural Killer Cell Infusions After Autologous Stem Cell Transplant for Hematological Malignancies
Natural killer cells are blood cells that are responsible for eliminating cancer cells
especially when there are only a few. It has been shown that NK cells coming from a
"mismatched" person (a relative) have a better chance than the patient's own NK cells to
recognize and kill cancer cells. These cells will be collected from the blood of a parent,
child or sibling and after preparation in the laboratory, will be given to the patient early
after an autologous stem cell transplantation like a blood or platelet transfusion. A person
who has been diagnosed with a blood tumor and received an autologous stem cell transplant
has the chance of his/her cancer coming back. This study uses NK cells obtained from a
relative to prevent disease recurrence by potentially eliminating and eradicating any
residual cancerous cells.
Interventional
Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
An evaluation of general safety will be undertaken: · Number of systemic clinical and biological adverse events occurring during the study. · Number of patients who prematurely discontinued study treatment for reasons linked to the general safety.
58 days post infusion of allogeneic NK-cells
Yes
Hans Klingemann, MD, PhD
Principal Investigator
Tufts Medical Center
United States: Food and Drug Administration
Allogeneic NKCell post ABMT
NCT00660166
April 2006
June 2012
Name | Location |
---|---|
Tufts Medical Center | Boston, Massachusetts 02111 |