Optimizing Body Composition & Health After Breast Cancer
As a result of treatment, breast cancer survivors typically experience unhealthy changes in
body composition (bone, muscle and fat). Treatments disrupt normal bone and energy balance
resulting in bone and muscle wasting and fat gain. Premenopausal women are at greatest risk
for these declines because most are thrust into early menopause from chemotherapy. Hormone
manipulation therapy (i.e., tamoxifen or arimidex) may further affect these tissues.
Exercise can prevent bone and muscle loss and promote fat loss. However, the ability of
exercise to reverse unfavorable changes in all components of body composition in women
experiencing early menopause from breast cancer treatment has not been specifically studied.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Supportive Care
Bone mineral density (lumbar spine, proximal femur), bone turnover markers (serum osteocalcin, urinary deoxypyridinoline cross-links) muscle mass, fat mass.
Kerri M Winters, PhD
Oregon Health and Science University
United States: Institutional Review Board
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