Know Cancer

forgot password

A Phase 1, Open-Label, Non-Randomized Study of OPB-31121 in Patients With Advanced Solid Tumors

Phase 1
19 Years
Open (Enrolling)
Solid Tumor

Thank you

Trial Information

A Phase 1, Open-Label, Non-Randomized Study of OPB-31121 in Patients With Advanced Solid Tumors

Inclusion Criteria

Inclusion Criteria

1. Histologically confirmed solid tumor refractory to standard therapy or for which
there is no standard therapy

2. Age: more than 19 years

3. ECOG performance status: less than 2

4. Life expectancy of longer than 3 months

5. Adequate vital organ function as follows:

- Bone marrow function

- neutrophils: more than 1,500 per microliter

- platelets: more than 75,000 per microliter

- hemoglobin: more than 10.0g per deciliter

- Hepatic function

- AST and ALT: less than 2.5 x institutional upper limit normal

- serum total bilirubin: less than 2.5 x institutional ULN

- Renal function

- Serum creatinine: less than 1.5 x institutional ULN

6. Capable of swallowing OPB-31121 tablets

7. Ability to understand and willingness to sign written informed consent document for
participation in the trial and for analysis of genotypes CYP2C9 and NAT2

8. No chemotherapy, radiotherapy, surgery, or immunotherapy within 4 weeks prior to
study entry and recovered from any prior toxicity

Exclusion criteria:

1. Symptomatic CNS metastasis

2. Uncontrolled concurrent illness, including active infection, heart failure, angina
pectoris, and cardiac arrhythmia

3. Psychiatric illness that would limit compliance with study requirements

4. Pregnant or breast-feeding women and women of childbearing potential who cannot or
will not use effective contraceptive measures

5. Administration of another investigational agent within 6 months prior to study entry

6. Use of CYP3A4 and CYP2C9 inducers, inhibitors, or substrates, and CYP2B6, CYP2C8 and
CYP2D6 substrates

7. Hyperlipidemia:

Total cholesterol:more than 300 milligram per deciliter or Triglycerides:

more than 2.5 x institutional ULN

8. Abnormal thyroid function: Hypothyroidism or hyperthyroidism of grade 2 or higher
(graded according to the NCI-CTCAE)

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Maximum tolerated dose

Outcome Time Frame:

Cycle 1

Safety Issue:


Principal Investigator

Yung-Jue Bang, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Division of Hematology and Medical Oncology, Seoul National University Hospital


Korea: Food and Drug Administration

Study ID:




Start Date:

March 2008

Completion Date:

June 2009

Related Keywords:

  • Solid Tumor
  • Neoplasms