Inclusion Criteria:

1. Women with diagnosis of breast cancer

2. Undergoing adjuvant/neoadjuvant chemotherapy with either FEC, FAC, TAC, or EC +
docetaxel combinations.

3. ≥ 18 years of age

4. Performance status: 0-2

5. Ability to provide written informed consent

Exclusion Criteria:

1. Any prior history of yunzhi use

2. Use of other herbal remedies during the study duration

3. Significant cardiac, pulmonary, renal, hepatic, gastrointestinal, CNS, psychiatric
disease or illicit substance use/abuse that in the opinion of the investigator would
make the participant a poor candidate for study participation

4. Pregnancy (for women of childbearing potential, a negative pregnancy test, urine or
serum, is required within 14 days prior to randomization)

5. Systemic use of progestins, androgens or other steroids (dexamethasone is allowed if
used as antiemetic therapy)