BREAST CANCER AND EXERCISE BREX: A Multicenter Phase III Open Randomised Trial of the Efficacy of Exercise in the Prevention of Long-Term Adverse Effects of Adjuvant Treatments and Breast Cancer Recurrences in Women With Primary Breast Cancer.
A multicenter phase III open randomised trial of the efficacy of exercise in the prevention
of long-term adverse effects of adjuvant treatments and breast cancer recurrences in women
with primary breast cancer. The aim of the study is to investigate whether regular exercise
training could reduce the long-term side effects of adjuvant treatments of primary breast
cancer and improve quality of life and well being. Large controlled prospective studies are
needed to confirm the preliminary findings of exercises benefits in cancer patients, and to
investigate the type, the frequency, intensity and tolerability of exercise training in
cancer patients, before any clinical recommendations can be given. Prevention of
osteoporosis, improvement of weight control, and muscular and cardiovascular fitness is been
waited. The second aim of the study is to investigate, whether regular exercise training
reduces the risk of breast cancer recurrence, prevents other diseases and reduce all-cause
mortality and is cost effective in women with primary breast cancer.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
The aim of the study is to investigate whether regular exercise after adjuvant treatments of breast cancer could prevent osteoporosis and improve quality of life.
Tiina Saarto, MD, PhD
Helsinki University Central Hospital, Department of Oncology
Finland: The Ethical Committee of Helsinki University (non-drug study)
Protocol number FBCSG-01-2004