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Clinical Implementation and Evaluation of MR Spectroscopy for Breast Cancer Detection

18 Years
70 Years
Open (Enrolling)
Breast Tumors

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Trial Information

Clinical Implementation and Evaluation of MR Spectroscopy for Breast Cancer Detection

Recent in vivo studies have reported successful use of 1H and 31P MRS in differentiating
between benign and malignant tumors in breast tissue. These studies demonstrated an
increase in the choline metabolite peak that reflects an increase in choline-containing
metabolites in 70-80% of breast carcinomas, as compared to 14-18% of benign breast
tumors.The objectives would be to determine sensitivity/specificity of MRS in the context of
breast CA, We will use normal volunteers to test software and to develop and optimize MR
scan sequences prior to or during the testing of target subjects with suspicious breast

Inclusion Criteria:

- subjects should have well defined suspicious breast lesion and that will be biopsied

- subjects are to include; varied volunteers with different breast tissue with
characteristics such as dense breasts, fibrocystic breasts, "small" breasted and
"large" breasted women.

Exclusion Criteria:

- Women of childbearing potential who are not practicing a medically accepted method of
birth control should not participate

- Subjects that are pregnant, breast-feeding, should not be able to participate

- Subjects having any of the following metallic devices, will be ineligible to
participate in the study: pacemaker, prosthesis, artificial heart valve, coronary
artery stents, TENS (Transcutaneous electric nerve stimulator) or other neurological
stimulation units and surgical clips.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Principal Investigator

Andrzej Krol, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

State University of New York - Upstate Medical University


United States: Institutional Review Board

Study ID:




Start Date:

November 2003

Completion Date:

Related Keywords:

  • Breast Tumors
  • breast
  • diagnostic radiology
  • suspicious breast tumors
  • MRI
  • Breast Neoplasms



SUNY Upstate Medical University Syracuse, New York  13210