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Detection of Chemotherapy Induced Cardiotoxicity


N/A
18 Years
N/A
Not Enrolling
Both
Cancer

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Trial Information

Detection of Chemotherapy Induced Cardiotoxicity


To identify patients at risk of development of heart damage after receiving chemotherapy by
obtaining the genetic profile of those who show: elevation of troponin, left ventricular
systolic and diastolic dysfunction, and pro-oxidant stress markers.


Inclusion Criteria:



- undergoing anthracycline and/or trastuzumab therapy for the first time

Exclusion Criteria:

- abnormal ventricular ejection fraction

- past history of, or active cardiac disease including: MI, CHF, angina, arrhythmia
requiring medication, valvular disease, uncontrolled systemic hypertension

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

The genetic profile of patients with anthracycline-induced elevation of troponin-I

Outcome Time Frame:

one year

Safety Issue:

Yes

Principal Investigator

Jannet Lewis, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

George Washington University

Authority:

United States: Institutional Review Board

Study ID:

JL-001

NCT ID:

NCT00636844

Start Date:

January 2008

Completion Date:

June 2012

Related Keywords:

  • Cancer
  • chemotherapy, cardiotoxicity

Name

Location
George Washington University Washington, District of Columbia  20037