Inclusion Criteria:

- Age ≥ 18 years

- Histologically confirmed metastatic colorectal cancer (CRC)

- Representative tumor specimens in paraffin blocks (preferred) or at least 15
unstained slides, with an associated pathology report, must be confirmed to be
available and requested at any time prior to entry of study

- Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

- Adequate hematopoetic capacity

- Adequate hepatic function

- Adequate renal function

- Use of an effective method of barrier contraception (for women of childbearing
potential)

- Signed informed consent

Exclusion Criteria:

- Prior chemotherapy for metastatic CRC or adjuvant chemotherapy for CRC within the
prior 6 months

- Clinically suspected or confirmed CNS metastases or carcinomatous meningitis

- Major surgical procedure within 4 weeks prior to the first day of treatment in this
study (Day 1)

- Pelvic radiation within 2 weeks prior to Day 1

- Wound dehiscence requiring intervention, gastrointestinal perforation, or bowel
obstruction

- Pregnancy or lactation

- Uncontrolled medical illnesses including the following: Infection requiring
intravenous (IV) antibiotics, congestive heart failure not controlled with
medication, hypertension not controlled with medication

- Thromboembolic disease

- History of other disease, metabolic dysfunction, physical examination finding, or
clinical laboratory finding giving reasonable suspicion of a disease or condition
that contraindicates use of an investigational drug or that might affect
interpretation of the results of the study or render the patient at high risk from
treatment complications