Inclusion Criteria:

- histologically or cytologically confirmed recurrent or metastatic head and neck
squamous carcinoma or nasopharyngeal carcinoma

- the tumor was amenable to direct injection and measurement ( > 2 cm)

- an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2

- a life expectancy over three months

- the absence of serious medical or psychiatric disorders

- serum creatinine < 1.5 mg/dL; WBC count >3,000/mm3, platelet count > 80,000/mm3,
hemoglobin > 8 g/dL; total bilirubin value < 1.5 times the upper limit of normal
[ULN], ALT level < 2.5 times ULN, AST < 2.5 times ULN.

Exclusion Criteria:

- pregnant or breast feeding

- a history of brain metastases or a primary brain tumor

- a history of hemorrhagic diathesis

- a history of corticosteroids or immunosuppressives use within four weeks of study
entry

- a history of immune deficiency disorder or organ transplant

- has evidence of active adenovirus infection or uncontrolled infection

- received any chemotherapy or radiotherapy within four weeks of study entry