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Investigation of the Immune Response to Gastrointestinal Tumors and Development of Novel Biomarkers for the Presence of Gastrointestinal Cancer


N/A
18 Years
N/A
Open (Enrolling)
Both
GI Cancer

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Trial Information

Investigation of the Immune Response to Gastrointestinal Tumors and Development of Novel Biomarkers for the Presence of Gastrointestinal Cancer


The first goal of this proposal is to collect cells from the peripheral blood, tumor
draining lymph nodes and tumor infiltrating lymphocytes in patients with early or late stage
gastrointestinal cancers. These samples will be evaluated in a variety of immunological
assays to better understand the immune response to these two cancers. The second goal of
this proposal is to evaluate using novel proteomic, cellomic, and genomic techniques the
serum and peripheral blood lymphocytes of these patients for protein, cellular changes and
genetic markers that correlate with the presence of cancer. The information gathered from
these studies will directly enhance our ability to design, conduct and monitor novel
immunotherapeutic protocols for the treatment of patients with gastrointestinal cancer.


Inclusion Criteria:



- histologically confirmed GI malignancy

- suspected GI malignancy

- high risk individual as assessed by their physician

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Cross-Sectional

Outcome Measure:

The first goal of this proposal is to collect cells from the peripheral blood, tumor draining lymph nodes and tumor infiltrating lymphocytes in patients with early or late stage gastrointestinal cancers.

Outcome Time Frame:

1 N/A

Safety Issue:

No

Principal Investigator

Herber J. Zeh, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Pittsburgh

Authority:

United States: Institutional Review Board

Study ID:

02-077

NCT ID:

NCT00633334

Start Date:

September 2003

Completion Date:

September 2013

Related Keywords:

  • GI Cancer
  • Cancer
  • GI
  • Tumor
  • Gastrointestinal
  • high risk
  • Gastrointestinal Neoplasms

Name

Location

University of Pittsburgh Cancer InstitutePittsburgh, Pennsylvania  15213