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Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide

Phase 3
18 Years
Open (Enrolling)
Lung Cancer

Thank you

Trial Information

Phase III Comparison of Thoracic Radiotherapy Regimens in Patients With Limited Small Cell Lung Cancer Also Receiving Cisplatin and Etoposide



- To determine whether administering high-dose thoracic radiotherapy, 70 Gy (2 Gy once
daily over 7 weeks) or 61.2 Gy (1.8 Gy once daily for 16 days followed by 1.8 Gy twice
daily for 9 days), will improve median and 2-year survival compared with 45 Gy (1.5 Gy
twice daily over 3 weeks) in patients with limited-stage small cell lung cancer.


- To compare treatment-related toxic effects of thoracic radiotherapy regimens in
patients with limited-stage small cell lung cancer.

- To compare response rates, failure-free survival, and toxicity of thoracic radiotherapy
regimens in patients with limited-stage small cell lung cancer.

- To compare rates of local relapse, distant metastases, and brain metastases with these

- To describe the patterns of use of thoracic intensity-modulated radiotherapy (IMRT) in
patients with limited-stage small cell lung cancer.

OUTLINE: This is a 2-part, multicenter, randomized study. Patients are stratified according
to gender, weight loss 6 months prior to study entry (≤ 5% of body weight vs > 5% of body
weight), ECOG performance status (0 vs 1 vs 2), radiotherapy technique (intensity-modulated
radiotherapy vs 3-dimensional conformal radiotherapy), and radiotherapy start time (at first
course of protocol chemotherapy, after one course of prior non-protocol chemotherapy vs at
first course of protocol chemotherapy, without prior non-protocol chemotherapy vs at second
course of protocol chemotherapy, without prior non-protocol chemotherapy).

- Part 1: Patients are randomized to 1 of 3 treatment arms.

- Arm I: Patients undergo standard-dose (45 Gy given in 30 treatments) thoracic
radiotherapy twice daily, 5 days a week, for 3 weeks. Patients also receive
cisplatin IV on day 1 and etoposide IV on days 1, 2, and 3.

- Arm II: Patients undergo higher-dose (70 Gy given in 35 treatments) thoracic
radiotherapy once daily, 5 days a week, for 7 weeks. Patients also receive
cisplatin and etoposide as in arm I.

- Arm III: (discontinued as of 03/10/13) Patients undergo higher-dose (61.2 Gy given
in 34 treatments) thoracic radiotherapy once daily, 5 days a week, during the
initial 16 days (approximately 3 weeks) of treatment and then twice daily, 5 days
a week, for the final 9 days (approximately 2 weeks) of treatment. Patients also
receive cisplatin and etoposide as in arm I.

In all arms, treatment with cisplatin and etoposide repeats every 21 days for 4 courses in
the absence of disease progression or unacceptable toxicity.

- Part 2: An interim analysis was conducted after accrual of 30 patients per arm and one
experimental arm based upon a comparison of treatment-related toxicity was selected.
The most toxic experimental arm was discontinued, and the trial continues comparing
standard therapy (arm I) to the selected experimental regimen (arm II) as described in
part 1.

Prophylactic radiotherapy: Within 3-6 weeks after completion of chemotherapy, patients with
responding disease are eligible to undergo prophylactic radiotherapy to the brain once a
day, 5 days a week, for 2 weeks.

After completion of study treatment, patients are followed up at least every 3 months for 2
years, every 6 months for 3 years, and then annually for 5 years or until disease
progression. At disease progression, patients are followed up every 6 months.

Inclusion Criteria


- Histologically or cytologically documented small cell lung cancer (SCLC)

- Limited-stage disease

- Disease restricted to one hemithorax with regional lymph node metastases,
including ipsilateral hilar, ipsilateral and contralateral mediastinal, and
ipsilateral supraclavicular lymph nodes

- The following patients are not eligible:

- Patients with disease involvement of the contralateral hilar or supraclavicular
lymph nodes

- Patients with pleural effusions that are visible on plain chest radiographs,
whether cytologically positive or not

- Patients with cytologically positive pleural or pericardial fluid, regardless of
the appearance on plain x-ray

- Measurable disease, defined as at least one unidimensionally measurable lesion ≥ 2 cm
by conventional techniques OR ≥ 1 cm by spiral CT scan


- Eastern Cooperative Oncology Group (ECOG) performance status 0-2

- Granulocytes ≥ 1,500/µl

- Platelet count ≥ 100,000/µl

- Total bilirubin ≤ 1.5 times upper limit of normal (ULN)

- AST ≤ 2.0 times ULN

- Serum creatinine ≤ 1.5 times ULN OR creatinine clearance ≥ 70 mL/min

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception


- Patients may have received one and only one course of chemotherapy prior to enrolling
on CALGB 30610, which must have included cisplatin and etoposide

- If a patient has had one course of cisplatin/etoposide prior to registration,
the patient must have had all of the prior-to-registration tests prior to
starting their first course of chemotherapy

- Registration to CALGB-30610 must take place within 14-21 days after the start of
the non-protocol therapy; failing to do all of the above will make the patient
NOT eligible for CALGB-30610

- No prior radiotherapy or chemotherapy (except for the chemotherapy described above)
for SCLC

- No prior mediastinal or thoracic radiotherapy

- No prior complete surgical resection of SCLC

Type of Study:


Study Design:

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Overall survival time between 3 treatment arms

Outcome Time Frame:

Up to 10 years

Safety Issue:


Principal Investigator

Jeffrey A. Bogart, MD

Investigator Role:

Study Chair

Investigator Affiliation:

State University of New York - Upstate Medical University


United States: Food and Drug Administration

Study ID:




Start Date:

March 2008

Completion Date:

Related Keywords:

  • Lung Cancer
  • limited stage small cell lung cancer
  • Lung Neoplasms
  • Small Cell Lung Carcinoma



Albert Einstein College of Medicine Bronx, New York  10461
Memorial Sloan Kettering Cancer Center New York, New York  10021
Cleveland Clinic Foundation Cleveland, Ohio  44195
University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan  48109-0752
Mayo Clinic Scottsdale Scottsdale, Arizona  85259
University of Chicago Cancer Research Center Chicago, Illinois  60637
Barbara Ann Karmanos Cancer Institute Detroit, Michigan  48201
Washington University School of Medicine Saint Louis, Missouri  63110
Cleveland Clinic Cancer Center Cleveland, Ohio  44195
CCOP - Upstate Carolina Spartanburg, South Carolina  29303
CCOP - Wichita Wichita, Kansas  67214-3882
Hurley Medical Center Flint, Michigan  48503
University of Texas Health Science Center at San Antonio San Antonio, Texas  78284-7811
CCOP - Missouri Valley Cancer Consortium Omaha, Nebraska  68131
CCOP - Christiana Care Health Services Wilmington, Delaware  19899
CCOP - Mount Sinai Medical Center Miami Beach, Florida  33140
CCOP - Illinois Oncology Research Association Peoria, Illinois  61602
CCOP - Metro-Minnesota Saint Louis Park, Minnesota  55416
Aurora Presbyterian Hospital Aurora, Colorado  80012
Boulder Community Hospital Boulder, Colorado  80301-9019
Penrose Cancer Center at Penrose Hospital Colorado Springs, Colorado  80933
Porter Adventist Hospital Denver, Colorado  80210
Presbyterian - St. Luke's Medical Center Denver, Colorado  80218
St. Joseph Hospital Denver, Colorado  80218
Swedish Medical Center Englewood, Colorado  80110
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center Grand Junction, Colorado  81502
Sky Ridge Medical Center Lone Tree, Colorado  80124
Hope Cancer Care Center at Longmont United Hospital Longmont, Colorado  80502
St. Mary - Corwin Regional Medical Center Pueblo, Colorado  81004
North Suburban Medical Center Thornton, Colorado  80229
CCOP - Michigan Cancer Research Consortium Ann Arbor, Michigan  48106
Saint Joseph Mercy Cancer Center Ann Arbor, Michigan  48106-0995
Oakwood Cancer Center at Oakwood Hospital and Medical Center Dearborn, Michigan  48123-2500
Genesys Hurley Cancer Institute Flint, Michigan  48503
Van Elslander Cancer Center at St. John Hospital and Medical Center Grosse Pointe Woods, Michigan  48236
Bronson Methodist Hospital Kalamazoo, Michigan  49007
West Michigan Cancer Center Kalamazoo, Michigan  49007-3731
Borgess Medical Center Kalamazooaa, Michigan  49001
Sparrow Regional Cancer Center Lansing, Michigan  48912-1811
St. John Macomb Hospital Warren, Michigan  48093
MeritCare Bemidji Bemidji, Minnesota  56601
Fairview Ridges Hospital Burnsville, Minnesota  55337
Mercy and Unity Cancer Center at Mercy Hospital Coon Rapids, Minnesota  55433
Fairview Southdale Hospital Edina, Minnesota  55435
Mercy and Unity Cancer Center at Unity Hospital Fridley, Minnesota  55432
HealthEast Cancer Care at St. John's Hospital Maplewood, Minnesota  55109
Hennepin County Medical Center - Minneapolis Minneapolis, Minnesota  55415
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital Minneapolis, Minnesota  55407
St. Francis Cancer Center at St. Francis Medical Center Shakopee, Minnesota  55379
Park Nicollet Cancer Center St. Louis Park, Minnesota  55416
Regions Hospital Cancer Care Center St. Paul, Minnesota  55101
United Hospital St. Paul, Minnesota  55102
Ridgeview Medical Center Waconia, Minnesota  55387
MeritCare Broadway Fargo, North Dakota  58122
CCOP - MeritCare Hospital Fargo, North Dakota  58122
Aultman Cancer Center at Aultman Hospital Canton, Ohio  44710-1799
Case Comprehensive Cancer Center Cleveland, Ohio  44106-5065
Natalie Warren Bryant Cancer Center at St. Francis Hospital Tulsa, Oklahoma  74136
Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania  19104-4283
Sanford Cancer Center at Sanford USD Medical Center Sioux Falls, South Dakota  57117-5039
Medical College of Wisconsin Cancer Center Milwaukee, Wisconsin  53226
CCOP - Ochsner New Orleans, Louisiana  70121
CCOP - Bay Area Tumor Institute Oakland, California  94609-3305
Methodist Medical Center of Illinois Peoria, Illinois  61636
Memorial Hospital of South Bend South Bend, Indiana  46601
CCOP - Montana Cancer Consortium Billings, Montana  59101
Fox Chase Cancer Center at Virtua-Memorial Hospital Burlington County Mount Holly, New Jersey  08060
CCOP - Columbus Columbus, Ohio  43206
Delaware County Memorial Hospital Drexel Hill, Pennsylvania  19026
Harrington Cancer Center Amarillo, Texas  79106
University of Texas Medical Branch Galveston, Texas  77555-1329
CCOP - Northern Indiana CR Consortium South Bend, Indiana  46601
Saint Joseph Regional Medical Center South Bend, Indiana  46617
UMASS Memorial Cancer Center - University Campus Worcester, Massachusetts  01605-2982
Ellis Fischel Cancer Center at University of Missouri - Columbia Columbia, Missouri  65203
Charles M. Barrett Cancer Center at University Hospital Cincinnati, Ohio  45267-0526
Cleveland Clinic Taussig Cancer Center Cleveland, Ohio  44195
MBCCOP - LSU Health Sciences Center New Orleans, Louisiana  70112
Kaiser Permanente Medical Center - Vallejo Vallejo, California  94589
Peninsula Regional Medical Center Salisbury, Maryland  21801
Veterans Affairs Medical Center - Buffalo Buffalo, New York  14215
Veterans Affairs Medical Center - Syracuse Syracuse, New York  13210
Rebecca and John Moores UCSD Cancer Center La Jolla, California  92093-0658
University of California Davis Cancer Center Sacramento, California  95817
Wesley Medical Center Wichita, Kansas  67214
Veterans Affairs Medical Center - Baltimore Baltimore, Maryland  21201
Kaiser Permanente Medical Center - San Francisco Geary Campus San Francisco, California  94115
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences Little Rock, Arkansas  72205
Thompson Cancer Survival Center Knoxville, Tennessee  37916
James Graham Brown Cancer Center at University of Louisville Louisville, Kentucky  40202
McDowell Cancer Center at Akron General Medical Center Akron, Ohio  44307
Lake/University Ireland Cancer Center Mentor, Ohio  44060
Mercy Fitzgerald Hospital Darby, Pennsylvania  19023
Kaiser Permanente Medical Center - Oakland Sacramento, California  95825
Florida Hospital Cancer Institute at Florida Hospital Orlando Orlando, Florida  32803-1273
Winship Cancer Institute of Emory University Atlanta, Georgia  30322
Advocate Christ Medical Center Oak Lawn, Illinois  60453
Via Christi Cancer Center at Via Christi Regional Medical Center Wichita, Kansas  67214
Alvin and Lois Lapidus Cancer Institute at Sinai Hospital Baltimore, Maryland  21215
SUNY Upstate Medical University Hospital Syracuse, New York  13210
Mission Hospitals - Memorial Campus Asheville, North Carolina  28801
Presbyterian Cancer Center at Presbyterian Hospital Charlotte, North Carolina  28233-3549
Wake Forest University Comprehensive Cancer Center Winston-Salem, North Carolina  27157-1096
Hollings Cancer Center at Medical University of South Carolina Charleston, South Carolina  29425
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas Dallas, Texas  75390
St. Vincent Hospital Regional Cancer Center Green Bay, Wisconsin  54307-3508
James P. Wilmot Cancer Center at University of Rochester Medical Center Rochester, New York  14642
Green Bay Oncology, Limited - Escanaba Escanaba, Michigan  49431
Dickinson County Healthcare System Iron Mountain, Michigan  49801
St. Mary's Hospital Medical Center - Green Bay Green Bay, Wisconsin  54303
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center Green Bay, Wisconsin  54301-3526
Green Bay Oncology, Limited at St. Mary's Hospital Green Bay, Wisconsin  54303
Bay Area Cancer Care Center at Bay Area Medical Center Marinette, Wisconsin  54143
Green Bay Oncology, Limited - Oconto Falls Oconto Falls, Wisconsin  54154
Green Bay Oncology, Limited - Sturgeon Bay Sturgeon Bay, Wisconsin  54235
Parma Community General Hospital Parma, Ohio  44129
North Colorado Medical Center Greeley, Colorado  80631
McKee Medical Center Loveland, Colorado  80539
Baptist Cancer Institute - Jacksonville Jacksonville, Florida  32207
William Beaumont Hospital - Royal Oak Campus Royal Oak, Michigan  48073
Wayne Memorial Hospital, Incorporated Goldsboro, North Carolina  27534
Adena Regional Medical Center Chillicothe, Ohio  54601
Doctors Hospital at Ohio Health Columbus, Ohio  43228
Riverside Methodist Hospital Cancer Care Columbus, Ohio  43214
Grady Memorial Hospital Delaware, Ohio  43015
Strecker Cancer Center at Marietta Memorial Hospital Marietta, Ohio  45750
Licking Memorial Cancer Care Program at Licking Memorial Hospital Newark, Ohio  43055
Community Hospital of Springfield and Clark County Springfield, Ohio  45505
Genesis - Good Samaritan Hospital Zanesville, Ohio  43701
Greenebaum Cancer Center at University of Maryland Medical Center Baltimore, Maryland  21201
Kaiser Permanente Medical Center - Santa Clara Kiely Campus Santa Clara, California  95051-5386
M.D. Anderson Cancer Center at Orlando Orlando, Florida  32806
Curtis and Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center Savannah, Georgia  31403-3089
Swedish-American Regional Cancer Center Rockford, Illinois  61104-2315
Lucille P. Markey Cancer Center at University of Kentucky Lexington, Kentucky  40536-0093
Tulane Cancer Center Office of Clinical Research Alexandria, Louisiana  71315-3198
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute Boston, Massachusetts  02115
University of Mississippi Cancer Clinic Jackson, Mississippi  39216-4505
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis St. Louis, Missouri  63110
CCOP - Nevada Cancer Research Foundation Las Vegas, Nevada  89109-2306
Oklahoma University Cancer Institute Oklahoma City, Oklahoma  73104
M. D. Anderson Cancer Center at University of Texas Houston, Texas  77030-4009
Gundersen Lutheran Center for Cancer and Blood La Crosse, Wisconsin  54601
Kaiser Permanente Medical Center - Sacramento Sacramento, California  95825
Methodist Estabrook Cancer Center Omaha, Nebraska  68114-4199
Decatur Memorial Hospital Cancer Care Institute Decatur, Illinois  62526
Paoli Memorial Hospital Paoli, Pennsylvania  19301-1792
Elkhart General Hospital Elkhart, Indiana  46515
Howard Community Hospital Kokomo, Indiana  46904
Lakeland Regional Cancer Care Center - St. Joseph St. Joseph, Michigan  49085
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton Marlton, New Jersey  08053
Fox Chase Virtua Health Cancer Program at Virtua West Jersey Voorhees, New Jersey  08043
Cleveland Clinic Cancer Center at Fairview Hospital Cleveland, Ohio  44111
Mount Carmel Health - West Hospital Columbus, Ohio  43222
Hillcrest Cancer Center at Hillcrest Hospital Mayfield Heights, Ohio  44124
Rosenfeld Cancer Center at Abington Memorial Hospital Abington, Pennsylvania  19001
University Medical Center of Southern Nevada Las Vegas, Nevada  89102
All Saints Cancer Center at Wheaton Franciscan Healthcare Racine, Wisconsin  53405
Kaiser Permanente Medical Center - Hayward Hayward, California  94545
Alta Bates Summit Medical Center - Summit Campus Oakland, California  94609
Kaiser Permanente Medical Center - Redwood City Redwood City, California  94063
Kaiser Permanente Medical Center - Richmond Richmond, California  94801
Kaiser Permanente Medical Center - Roseville Roseville, California  95661
South Sacramento Kaiser-Permanente Medical Center Sacramento, California  95823
Kaiser Permanente Medical Center - Santa Teresa San Jose, California  95119
Kaiser Foundation Hospital - San Rafael San Rafael, California  94903
Kaiser Permanente Medical Center - Santa Rosa Santa Rosa, California  95403
Kaiser Permanente Medical Center - South San Francisco South San Francisco, California  94080
Kaiser Permanente Medical Facility - Stockton Stockton, California  95210
Kaiser Permanente Medical Center - Walnut Creek Walnut Creek, California  94596
Ella Milbank Foshay Cancer Center at Jupiter Medical Center Jupiter, Florida  33458
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center Boise, Idaho  83706
St. Joseph Medical Center Bloomington, Illinois  61701
Swedish Covenant Hospital Chicago, Illinois  60625
Eureka Community Hospital Eureka, Illinois  61530
BroMenn Regional Medical Center Normal, Illinois  61761
Community Cancer Center Normal, Illinois  61761
Community Hospital of Ottawa Ottawa, Illinois  61350
Oncology Hematology Associates of Central Illinois, PC - Ottawa Ottawa, Illinois  61350
Cancer Treatment Center at Pekin Hospital Pekin, Illinois  61554
Oncology Hematology Associates of Central Illinois, PC - Peoria Peoria, Illinois  61615
OSF St. Francis Medical Center Peoria, Illinois  61637
Proctor Hospital Peoria, Illinois  61614
Illinois Valley Community Hospital Peru, Illinois  61354
Valley Cancer Center Spring Valley, Illinois  61362
Center for Cancer Therapy at LaPorte Hospital and Health Services La Porte, Indiana  46350
Cancer Center of Kansas, PA - Dodge City Dodge City, Kansas  67801
Mary Bird Perkins Cancer Center - Baton Rouge Baton Rouge, Louisiana  70809
Medical Center of Louisiana - New Orleans New Orleans, Louisiana  70112
Providence Cancer Institute at Providence Hospital - Southfield Campus Southfield, Michigan  48075
Immanuel Medical Center Omaha, Nebraska  68122
Creighton University Medical Center Omaha, Nebraska  68131-2197
Cancer Institute of New Jersey at Cooper - Voorhees Voorhees, New Jersey  08043
Charles R. Wood Cancer Center at Glens Falls Hospital Glens Falls, New York  12801
Highland Hospital of Rochester Rochester, New York  14620
Iredell Memorial Hospital Statesville, North Carolina  28677
North Coast Cancer Care, Incorporated Sandusky, Ohio  44870
Cleveland Clinic - Wooster Wooster, Ohio  44691
Bryn Mawr Hospital Bryn Mawr, Pennsylvania  19010
Delaware County Regional Cancer Center at Delaware County Memorial Hospital Drexel Hill, Pennsylvania  19026
Bon Secours St. Francis Health System Greenville, South Carolina  29601
Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center Kingsport, Tennessee  37662
Massachusetts General Hospital Boston, Massachusetts  02114-2617
St. Anthony Central Hospital Denver, Colorado  80204-1335
Exempla Lutheran Medical Center Wheat Ridge, Colorado  80033
Trinity Medical Center Moline, Illinois  61265-1291
California Cancer Center - Woodward Park Office Fresno, California  93720
Northeast Georgia Medical Center Gainesville, Georgia  30501
Creticos Cancer Center at Advocate Illinois Masonic Medical Center Chicago, Illinois  60657
Cancer Center at Ball Memorial Hospital Muncie, Indiana  47303
Regional Cancer Center at Singing River Hospital Pascagoula, Mississippi  39581
Saint Luke's Hospital Chesterfield, Missouri  63017
Cancer Resource Center - Lincoln Lincoln, Nebraska  68510
Altru Cancer Center at Altru Hospital Grand Forks, North Dakota  58201
Cancer Treatment Center Wooster, Ohio  44691
UAB Comprehensive Cancer Center Birmingham, Alabama  35294
Stanford Cancer Center Stanford, California  94305-5824
Tunnell Cancer Center at Beebe Medical Center Lewes, Delaware  19958
Michael and Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital Fort Lauderdale, Florida  33308
John B. Amos Cancer Center Columbus, Georgia  31904
Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler Savannah, Georgia  31405
Evanston Hospital Evanston, Illinois  60201-1781
Michiana Hematology-Oncology, PC - Elkhart Elkhart, Indiana  46514
Elkhart Clinic, LLC Elkhart, Indiana  46514-2098
Michiana Hematology Oncology PC - La Porte La Porte, Indiana  46350
Michiana Hematology-Oncology, PC - South Bend Mishawaka, Indiana  46545-1470
Michiana Hematology Oncology PC - Plymouth Plymouth, Indiana  46563
Cancer Center of Kansas, PA - El Dorado El Dorado, Kansas  67042
Lawrence Memorial Hospital Lawrence, Kansas  66044
Menorah Medical Center Overland Park, Kansas  66209
Saint Luke's Hospital - South Overland Park, Kansas  66213
Cancer Center of Kansas, PA - Salina Salina, Kansas  67401
Cotton-O'Neil Cancer Center Topeka, Kansas  66606
Cancer Center of Kansas, PA - Wellington Wellington, Kansas  67152
Cancer Center of Kansas, PA - Wichita Wichita, Kansas  67214
Associates in Womens Health, PA - North Review Wichita, Kansas  67208
Cancer Center of Kansas, PA - Medical Arts Tower Wichita, Kansas  67208
Cancer Center of Kansas, PA - Winfield Winfield, Kansas  67156
Greater Baltimore Medical Center Cancer Center Baltimore, Maryland  21204
Foote Memorial Hospital Jackson, Michigan  49201
St. Mary Mercy Hospital Livonia, Michigan  48154
St. Joseph Mercy Oakland Pontiac, Michigan  48341-2985
Seton Cancer Institute at Saint Mary's - Saginaw Saginaw, Michigan  48601
Lakeside Cancer Specialists, PLLC Saint Joseph, Michigan  49085
Willmar Cancer Center at Rice Memorial Hospital Willmar, Minnesota  56201
Heartland Hematology Oncology Associates, Incorporated Kansas City, Missouri  64118
North Kansas City Hospital Kansas City, Missouri  64116
Saint Luke's Cancer Institute at Saint Luke's Hospital Kansas City, Missouri  64111
Research Medical Center Kansas City, Missouri  64132
Saint Luke's East - Lee's Summit Lee's Summit, Missouri  64086
Heartland Regional Medical Center Saint Joseph, Missouri  64506
Saint Joseph Oncology, Incorporated Saint Joseph, Missouri  64507
Billings Clinic - Downtown Billings, Montana  59107-7000
Alegant Health Cancer Center at Bergan Mercy Medical Center Omaha, Nebraska  68124
Summa Center for Cancer Care at Akron City Hospital Akron, Ohio  44309-2090
Barberton Citizens Hospital Barberton, Ohio  44203
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center Columbus, Ohio  43210-1240
Grant Medical Center Cancer Care Columbus, Ohio  43215
Mount Carmel St. Ann's Cancer Center Westerville, Ohio  43081
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center Hershey, Pennsylvania  17033-0850
York Cancer Center at Apple Hill Medical Center York, Pennsylvania  17405
Southwest Virginia Regional Cancer Center at Wellmonth Health Norton, Virginia  24273
FirstHealth Moore Regional Community Hospital Comprehensive Cancer Center Pinehurst, North Carolina  28374
Mid Dakota Clinic, PC Bismarck, North Dakota  58501
Regional Cancer Center at Memorial Medical Center Springfield, Illinois  62781-0001
John H. Stroger, Jr. Hospital of Cook County Chicago, Illinois  60612-9985
Elliot Regional Cancer Center at Elliot Hospital Manchester, New Hampshire  03103
Pardee Memorial Hospital Hendersonville, North Carolina  28791
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center Spartanburg, South Carolina  29303
Union Hospital of Cecil County Elkton MD, Maryland  21921
Dana-Farber/Brigham and Women's Cancer Center Boston, Massachusetts  02115
Duke Cancer Institute Durham, North Carolina  27710
Kinston Medical Specialists Kinston, North Carolina  28501
Resurrection Medical Center Chicago, Illinois  60631
Wellmont Holston Valley Hospital and Medical Center Kingsport, Tennessee  37662
Highlands Oncology Group - Springdale Springdale, Arkansas  72764
La Grange Memorial Hospital La Grange, Illinois  60525
University of Wisconcin Cancer Center at Aspirus Wausau Hospital Wausau, Wisconsin  54401
Integrated Community Oncology Network Jacksonville Beach, Florida  32250
Baptist Medical Center South Jascksonville, Florida  32258
Florida Cancer Center - Palatka Palatka, Florida  32177
Flagler Cancer Center Saint Augustine, Florida  32086
Center for Cancer Care at OSF Saint Anthony Medical Center Rockford, Illinois  61108
Doctors Medical Center - San Pablo Campus San Pablo, California  94806
Galesburg Clinic, PC Galesburg, Illinois  61401
Providence Cancer Center at Providence Hospital Mobile, Alabama  36608
East Bay Radiation Oncology Center Castro Valley, California  94546
Contra Costa Regional Medical Center Martinez, California  94553-3156
Memorial Medical Center Modesto, California  95355
El Camino Hospital Cancer Center Mountain View, California  94040
Larry G Strieff MD Medical Corporation Oakland, California  94609
Tom K Lee, Incorporated Oakland, California  94609
Bay Area Breast Surgeons, Incorporated Oakland, California  94609
Illinois CancerCare - Bloomington Bloomington%, Illinois  61701
Illinois CancerCare - Canton Canton, Illinois  61520
Illinois CancerCare - Eureka Eureka, Illinois  61530
Illinois CancerCare - Macomb Macomb, Illinois  61455
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus Moline, Illinois  61265
Illinois CancerCare - Community Cancer Center Normal, Illinois  61761
Illinois CancerCare - Pekin Pekin, Illinois  61603
Illinois CancerCare - Peru Peru, Illinois  61354
Illinois CancerCare - Spring Valley Spring Valley, Illinois  61362
Caritas St. Elizabeth's Medical Center Brighton, Massachusetts  02135-2997
Christian Hospital Northeast Cancer Care Center Saint Louis, Missouri  63136
Center for Cancer Care at Exeter Hospital Exeter, New Hampshire  03833
Trinity CancerCare Center Minot, North Dakota  58701
AnMed Cancer Center Anderson, South Carolina  29621
U.T. Medical Center Cancer Institute Knoxville, Tennessee  37920-6999
Dale and Frances Hughes Cancer Center at Pocono Medical Center East Stroudsburg, Pennsylvania  18301
Cancer Care Center, Incorporated Salem, Ohio  44460
Nebraska Methodist Hospital Omaha, Nebraska  68114
Medcenter One Hospital Cancer Care Center Bismarck, North Dakota  58501
St. Alexius Medical Center Cancer Center Bismarck, North Dakota  58502
Case Western Reserve University Cleveland, Ohio  44106
Veterans Affairs Medical Center - Milwaukee Milwaukee, Wisconsin  53295
Saint Mary's Regional Medical Center Reno, Nevada  89503
Integrated Community Oncology Network - Orange Park Orange Park, Florida  32073
Provena St. Mary's Regional Cancer Center - Kankakee Kankakee, Illinois  60901
Frankford Hospital Cancer Center - Torresdale Campus Philadelphia, Pennsylvania  19114
Minnesota Oncology - Maplewood Maplewood, Minnesota  55109
Humphrey Cancer Center at North Memorial Outpatient Center Robbinsdale, Minnesota  55422-2900
Minnesota Oncology - Woodbury Woodbury, Minnesota  55125
Tulane University Health Sciences Center New Orleans, Louisiana  70112
Lankenau Hospital Wynnewood, Pennsylvania  19096
UPMC Cancer Center at Beaver Medical Center Beaver, Pennsylvania  15009
UPMC - Shadyside Pittsburgh, Pennsylvania  15213-2582
Blue Ridge Medical Specialists, PC Bristol, Tennessee  37620
Emory Crawford Long Hospital Atlanta, Georgia  30308
CCOP - Kansas City Prairie Village, Kansas  66208
St. Agnes Hospital Cancer Center Baltimore, Maryland  21229
Renown Institute for Cancer at Renown Regional Medical Center Reno, Nevada  89502
Sands Cancer Center Canandiaqua, New York  14424
University Radiation Oncology at Parkridge Hospital Rochester, New York  14626
Coastal Carolina Radiation Oncology Center Wilmington, North Carolina  28401
Roy and Patricia Disney Family Cancer Center at Providence Saint Joseph Medical Center Burbank, California  91505
Langlade Memorial Hospital Antigo, Wisconsin  54409
Integrated Community Oncology Network at Southside Cancer Center Jacksonville, Florida  32207
Southwest General Health Center Middleburgh Heights, Ohio  44130
UHHS Chagrin Highlands Medical Center Orange Villager, Ohio  44122
UHHS Westlake Medical Center Westlaker, Ohio  44145
Clemens Regional Medical Center Mount Clemens, Michigan  48043
Lakeside Hospital Omaha, Nebraska  68130
Cleveland Clinic Foundation - Strongsville Strongsville, Ohio  44136
Littleton Adventist Hospital Littleton, Colorado  80122
Roger Maris Cancer Center at MeritCare Hospital Fargo, North Dakota  58122
OSF Saint Francis Medical Center Peoria, Illinois  61637
Saint Helena Hospital Saint Helena, California  94574
The Medical Center of Aurora Aurora, Colorado  80012
Saint Francis Hospital Evanston, Illinois  60202
Illinois CancerCare-Ottawa Clinic Ottawa, Illinois  61350
Ottawa Regional Hospital and Healthcare Center Ottawa, Illinois  61350
Illinois CancerCare-Peoria Peoria, Illinois  61615
Green Bay Oncology - Iron Mountain Iron Mountain, Michigan  49801
Cooper Hospital University Medical Center Camden, New Jersey  08103
Summa Barberton Hospital Barberton, Ohio  44203
Aria Health-Torresdale Campus Philadelphia, Pennsylvania  19114
Mainline Health CCOP Wynnewood, Pennsylvania  19096
Southwest VA Regional Cancer Center Norton, Virginia  24273
Southern Ohio Medical Center Cancer Center Portsmouth, Ohio  45662
Georgetown Memorial Hospital Georgetown, South Carolina  29440
Michiana Hematology Oncology PC-South Bend South Bend, Indiana  46601
New Hanover Regional Medical Center/Zimmer Cancer Center Wilmington, North Carolina  28401
Celilo Cancer Center at Mid-Columbia Medical Center The Dalles, Oregon  97058
Adams Cancer Center Gettysburg, Pennsylvania  17325
Cherry Tree Cancer Center Hanover, Pennsylvania  17331
Charles A. & Betty Bott Cancer Center at Holy Redeemer Hospital Meadowbrook, Pennsylvania  19046
Sanford Cancer Center Oncology Clinic Sioux Falls, South Dakota  57104
Saint Vincent Oncology Center Indianapolis, Indiana  46260
Dana-Farber/Brigham and Women's Cancer Center at Milford Regional Medical Center Milford, Massachusetts  01757
Zangmeister Center Columbus, Ohio  43219
Montefiore Medical Center - Moses Campus Bronx, New York  10467
Sanford Roger Maris Cancer Center Fargo, North Dakota  
Marie Yeager Cancer Center Saint Joseph, Michigan  49085
Sanford Clinic North-Fargo Fargo, North Dakota  58102
Sanford Medical Center-Fargo Fargo, North Dakota  58122
Dana-Farber/Brigham and Women's Cancer Center at South Shore South Weymouth, Massachusetts  02190
Botsford Cancer Center at Botsford Hospital Farmington, Michigan  48336-5919
South Atlantic Radiation Oncology Supply, North Carolina  28462
Memorial University Medical Center Savannah, Georgia  31404
Sanford Clinic North-Bemidgi Bemidji, Minnesota  56601
Sanford Bismarck Medical Center Bismarck, North Dakota  58501
Springfield Regional Medical Center Springfield, Ohio  45505
Memorial Sloan-Kettering Cancer Center at Suffolk Commack, New York  11725
Jameson Health System North Campus New Castle, Pennsylvania  16105
Benefis Sletten Cancer Institute Great Falls, Montana  59405
Hematology and Oncology Associates-Oakland Oakland, California  94609
Integrated Community Oncology Network-Cancer Center of Putnam Palatka, Florida  32177
Memorial Sloan Kettering Cancer Center at Basking Ridge Basking Ridge, New Jersey  07920
Memorial Sloan-Kettering Cancer Center Rockville Centre Rockville Centre, New York  11570
Memorial Sloan-Kettering Cancer Center at Phelps Sleepy Hollow, New York  10591
Cancer Care Center Incorporated Salem, Ohio  44460
Reading Hospital West Reading, Pennsylvania  19612
Saint Agnes Hospital/Agnesian Cancer Center Fond Du Lac, Wisconsin  54935
Westfields Hospital/Cancer Center of Western Wisconsin New Richmond, Wisconsin  54017