Trial Information

Compliance to Long Term Imatinib Therapy in Newly Diagnosed Patients With Chronic Myeloid Leukaemia.

We plan to follow prospectively a cohort of CML patients in order to study their compliance
to therapy,pharmacological levels of imatinib and the prevalence of side effects. We expect
to be able to correlate the actual dose received, the pharmacological levels of drug in
blood, with the change in the level of residual disease (measured by Q−PCR) at various time
points. We also want to gain insight into the relationship between compliance to therapy and
specific side effects and between compliance and duration of treatment. We will also assess
the adherence to imatinib therapy after increases in the drug dose that are part of standard
treatment.