Early Screening of Hepatocellular Carcinoma in Cirrhotic Patients: a Prospective Study
Well-diagnosed consecutive patients with cirrhosis were enrolled through a designed
questionnaire to obtain basic information about gender, age, etiology of cirrhosis,
conventional liver function tests, serum AFP level, education level, substance use including
smoking, alcohol drinking, betel quid chewing, history of familial HCC, etc. Then the
patients was followed by periodic abdominal sonography examination and determination of AFP
and liver function. If AFP elevated or liver nodule appears, effort to diagnose HCC will be
performed.If HCC was performed, the survival will be followed-up.
Observational Model: Case-Only, Time Perspective: Prospective
development of hepatocellular carcinoma
Jung-Fa Tsai, M.D., Ph.D.
Kaohsiung Medical University
Taiwan: Department of Health