Inclusion Criteria:

- The Samples used will be derived from three cohorts below and will only include
patients who have completed mastectomy or reconstruction within 1-5 years of
enrollment.

- Patients who have undergone immediate, two-stage expander/implant postmastectomy
reconstruction

- Patients who have undergone immediate, autogenous tissue flap reconstruction
following mastectomy

- Patients who have undergone mastectomy alone

- Patients at least 21 years of age

- Patients who completed mastectomy ± immediate post-mastectomy reconstruction at least
one year but no longer than five years prior to study entry

Exclusion Criteria:

- Patients who have had any of the following:

- delayed reconstruction (no reconstruction at time of surgery) combined autogenous
tissue/implant breast reconstruction, and/or

- Patients who have a pre-surgical history of complex regional pain syndrome

- Patients who have had radiation therapy

- Patients who have had a local recurrence

- Patients who do not speak the English language (validated translations of key
questionnaires are not available).