Inclusion Criteria:

- Signed written informed consent

- Patients with histologically or cytologically confirmed stage IV colorectal cancer
who have failed either irinotecan-based, oxaliplatin-based or both. ECOG performance
status of 0-2

- Presence of measurable disease by radiographic study (including CT or MRI scan, or
chest x-ray) or physical examination

- At least 3 weeks since last major surgery.

- At least 6 weeks since prior radiotherapy providing that the extent and site of
radiotherapy fields are such that marked bone marrow suppression is NOT expected.
Patients who have received palliative radiotherapy must have recovered from any
reversible toxic effects e.g. nausea and vomiting caused by radiation of fields.

- At least 4 weeks since prior chemotherapy.

- Pt with reproductive potential must use effective BC

- Required Screening Laboratory Criteria:

- Hemoglobin 9.0g/dL

- WBC 3,500/mm3 [ 3.5 x 109/L]

- Neutrophils 1,500/mm3 [1.5 x 109/L]

- Platelets 100,000/mm3 [ 100.0 x 109/L]

- Creatinine 1.5 mg/dL (133 micromol/L) AND creatinine clearance 60 mL/min

- A probable life expectancy of at least 6 months

Exclusion Criteria:

- No brain metastases.

- If female of childbearing potential, pregnancy test is negative.

- Concomitant malignancies or previous malignancies other than colorectal cancer within
the last five years, with the exception of adequately treated basal or squamous cell
carcinoma of the skin, carcinoma in situ of the cervix, or low grade prostate cancer.

- Active infection.

- Concurrent severe medical problems unrelated to the malignancy, which would
significantly limit full compliance with the study or expose the patient to extreme
risk.

- Sexually active patients refusing to practice adequate contraception. (condom plus
spermicide, or other form of birth control)

- Patients with conditions which might affect absorption of an oral drug (for example
intermittent obstruction) should be excluded unless discussed and agreed with the
principal investigator

- History of grade 3 or 4 toxicity to fluoropyrimidines.

- Pre-existing neuropathy ≥ NCI CTC grade 2.