Tennessee Colorectal Polyp Study
- To recruit 7,000 participants who are planning to undergo colonoscopy.
- To collect questionnaires and medical records from these participants.
- To collect biological samples, including urine, blood, buccal cells and/or saliva,
rectal tissue, and colorectal polyps from these participants.
- To evaluate risk factors and other differences between participants found to have
polyps and those who do not have polyps.
OUTLINE: Participants undergo screening colonoscopy and removal of any polyps.
Within 1 month of colonoscopy, participants undergo a 30-minute telephone interview and/or
complete a mail survey to provide information on lifestyle and medical history that may be
related to colorectal polyp risk. Participants who undergo removal of polyps during their
colonoscopy also complete a 20-minute survey at their 3-year follow-up colonoscopy.
Participants' medical records may also be reviewed.
Blood samples are collected at the time of colonoscopy. Some participants may also provide
blood samples 1-2 weeks prior to colonoscopy. Tissue from the bisected portions of
colorectal polyps > 5 mm in size that are removed during colonoscopy is also obtained. Some
participants may also undergo normal colorectal tissue sample and saliva sample collection
at the time of colonoscopy and urine sample collection 2 days prior to, during, and/or 8
weeks after colonoscopy.
Tissue samples may be stored for future genetic studies to evaluate genetic factors that may
cause or be related to colon polyps or colorectal cancer.
Recruitment of 7,000 participants who are planning to undergo colonoscopy
Wei Zheng, MD, PhD, MPH
Vanderbilt-Ingram Cancer Center
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Veterans Affairs Medical Center - Nashville||Nashville, Tennessee 37212|
|Vanderbilt-Ingram Cancer Center - Cool Springs||Nashville, Tennessee 37064|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|