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Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone


N/A
N/A
N/A
Not Enrolling
Both
Osteosarcoma, Paget's Disease

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Trial Information

Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone


As above, no additional information


Inclusion Criteria:



- This is a familial study therefore the only inclusion/exclusion criteria would be
that subjects must be a blood relative and over the age of 18.

- The subjects are proband and father along with unaffected blood relatives. Their
peripheral blood will act as a control and provide information to delineate the
inheritance from the father, as seen in the son.

Exclusion Criteria:

- Not part of the family

Type of Study:

Observational

Study Design:

Observational Model: Family-Based, Time Perspective: Prospective

Outcome Measure:

Loss of heterozygosity

Outcome Description:

A loss of heterozygosity of a proposed tumor suppressor gene on chromosome 18

Outcome Time Frame:

January, 2000 through February 2009

Safety Issue:

No

Principal Investigator

Timothy A Damron, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

State University of New York - Upstate Medical University

Authority:

United States: Institutional Review Board

Study ID:

Osteosarcoma & Paget's Disease

NCT ID:

NCT00615628

Start Date:

April 2002

Completion Date:

December 2009

Related Keywords:

  • Osteosarcoma
  • Paget's Disease
  • Inheritance of Osteosarcoma & Paget's Disease through Chromosome 18
  • Osteitis Deformans
  • Osteosarcoma

Name

Location
SUNY Upstate Medical University Syracuse, New York  13210