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Comparison of Pain Experienced by Patients Undergoing Endometrial Biopsy by Pipelle and Explora Curette

18 Years
85 Years
Not Enrolling

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Trial Information

Comparison of Pain Experienced by Patients Undergoing Endometrial Biopsy by Pipelle and Explora Curette

Is there a difference in pain perceived by patients undergoing endometrial biopsy via the
Pipelle or Explora curette? Currently, the instrument selected for endometrial biopsy is
solely dependent on provider preference. This study aims to elucidate advantages and/or
disadvantages of the Pipelle versus the Explora curette in terms of pain perceived by the
patient, adequacy of sample, and provider ease of use to better aid in the selection of the
appropriate device.

Inclusion Criteria:

- Women ages 18 and over who present to the OHSU Center for Women's Health and the
Portland Veteran's Affairs Medical Center with an indication for endometrial biopsy,
are literate in English or Spanish, who are willing to participate in the study.

Exclusion Criteria:

- Pregnancy, known or suspected

- Known cervical stenosis

- History of Mullerian tract anomalies

- History of uterine or cervical surgery

- Pelvic inflammatory disease (current or within the past 3 months)

- Sexually transmitted diseases (current)

- Puerperal or post abortion sepsis (current or within the past 3 months)

- Purulent cervicitis (current)

- Known clotting disorder

- Known uterine anomalies or fibroids distorting the cavity in a way incompatible
with office endometrial biopsy

- Allergy to any component of the Pipelle or Explora curette

- Patients who are premedicated with analgesics or misoprostol

- Patients who require mechanical cervical dilation or receive paracervical block

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Supportive Care

Outcome Measure:

Compare Pipelle and Explora curette groups with respect to patient perception of pain associated with the procedure as rated by a 10 cm visual analog scale.

Outcome Time Frame:

Two Years

Safety Issue:


Principal Investigator

Alison Edelman, MD, MPH

Investigator Role:

Principal Investigator

Investigator Affiliation:

Oregon Health and Science University


United States: Institutional Review Board

Study ID:




Start Date:

January 2009

Completion Date:

December 2010

Related Keywords:

  • Pain
  • endometrial biopsy
  • pain management
  • Adenoma



Oregon Health & Science University Portland, Oregon  97201
Portland Veterans Affairs Medical Center Portland, Oregon  97239