Inclusion Criteria:

- Subjects must have been previously treated with one line of systemic anti-cancer
therapy (non-experimental or experimental) for metastatic disease, and relapsed,
failed to respond (CR or PR) or did not tolerate that regimen. If the treatment has
been administered as an adjuvant and/or neoadjuvant therapy, the subject must have
documented disease progression from the last treatment and also received one
additional line of systemic therapy for metastatic disease.

- Men and women, who are at least 18 years of age

Exclusion Criteria:

- Ocular or mucosal melanoma

- Complete surgical resection of all identifiable sites of disease

- Symptomatic brain metastasis. Subjects with signs or symptoms suggestive of brain
metastasis are not eligible unless brain metastases are ruled out by computerized
axial tomography (CT) scan or magnetic resonance imaging (MRI). Subjects with stable
brain metastasis and those who were previously treated with radiotherapy or surgery
must have no current evidence of symptomatic brain metastasis and are off steroid
therapy for at least 4 weeks prior to randomization