Inclusion Criteria:

- Histologically confirmed diagnosis of 1 of the following malignant gliomas:

- Anaplastic astrocytoma

- Glioblastoma multiforme

- Oligodendroglioma

- Oligoastrocytoma

- WHO grade III or IV disease

- Newly diagnosed or recurrent disease

- Bidimensionally measurable disease by contrast-enhancing MRI

- Surgically accessible tumor for which resection is indicated

- Previously treated with or planning to undergo treatment with conventional external
beam radiotherapy

- HLA-A*201 positive

- Karnofsky performance status 60-100%

- Life expectancy ≥ 8 weeks

- Hemoglobin ≥ 10 g/dL

- Absolute granulocyte count ≥ 1,500/mm³

- Platelet count ≥ 100,000/mm³

- SGOT and SGPT ≤ 2 times normal

- Alkaline phosphatase ≤ 2 times normal

- Bilirubin ≤ 1.5 mg/dL

- BUN ≤ 1.5 times normal OR creatinine ≤ 1.5 times normal

- Negative pregnancy test

- Fertile patients must use effective contraception

- Hepatitis B negative

- Hepatitis C negative

- HIV negative

- Syphilis serology negative

- Afebrile

Exclusion Criteria:

- active infection

- immunodeficiency

- autoimmune disease that may be exacerbated by immunotherapy, including any of the
following:

- Rheumatoid arthritis

- Systemic lupus erythematosus

- Vasculitis

- Polymyositis-dermatomyositis

- Scleroderma

- Multiple sclerosis

- Juvenile-onset insulin-dependent diabetes

- allergy to study agents

- underlying condition that would contraindicate study therapy

- concurrent severe or unstable medical condition that would preclude giving informed
consent

- psychiatric condition that would preclude study participation or giving informed
consent

- other malignancy within the past 5 years except adequately treated basal cell or
squamous cell skin cancer, localized prostate cancer, or carcinoma in situ of the
cervix

- prior chemotherapy (6 weeks for nitrosoureas) within last 4 weeks of starting
treatment

- concurrent corticosteroids within 2 weeks prior to treatment

- radiotherapy within 2 weeks prior to treatment

- systemic antibiotics within 72 hours prior to treatment

- prior organ allograft

- antihistamine therapy within 5 days before or after administration of study vaccine

- chemotherapy during and for 4 weeks after administration of study vaccine

- adjuvant therapy during and for 4 weeks after administration of study vaccine

- other concurrent investigational agents