Inclusion Criteria:

- Cases will be eligible for inclusion if:

- They have been diagnosed with a second primary lung cancer, and

- They speak English or a language for which we have a translated consent form, and

- They understand and agree to sign informed consent, and

- They agree to give us a blood sample, and

- They agree to give us a tissue sample when part of normal clinical procedures, and

- They agree to complete the study questionnaires, and

- They agree to have their pathology information reviewed. This could include biopsy
specimens.

Controls will be eligible for inclusion if

- They have been diagnosed with a first primary lung cancer, and

- They speak English or a language for which we have a translated consent form, and

- They understand and agree to sign informed consent, and

- They agree to give us a blood sample, and

- They agree to give us a tissue sample when part of normal clinical procedures, and

- They agree to complete the study questionnaires,

- They agree to have their pathology information reviewed. This will could include
biopsy specimens.

Exclusion Criteria:

- Subjects who do not meet the inclusion criteria as either cases or controls will not
be eligible for this study.

- Control subjects who have a history of another cancer, other than nonmelanoma skin
cancer or a first primary lung cancer, will not be eligible for this study.

- Control subjects who otherwise meet the eligibility requirements above but who have
had chemotherapy and/or are currently being treated with chemotherapy will be
excluded from the functional assay, but not from the genotyping.