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DNA Repair and Genetic Susceptibility to Lung Cancer


N/A
N/A
N/A
Open (Enrolling)
Both
Lung Cancer, Single Primary Lung Cancer, Second Primary Lung Cancer

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Trial Information

DNA Repair and Genetic Susceptibility to Lung Cancer


Inclusion Criteria:



- Cases will be eligible for inclusion if:

- They have been diagnosed with a second primary lung cancer, and

- They speak English or a language for which we have a translated consent form, and

- They understand and agree to sign informed consent, and

- They agree to give us a blood sample, and

- They agree to give us a tissue sample when part of normal clinical procedures, and

- They agree to complete the study questionnaires, and

- They agree to have their pathology information reviewed. This could include biopsy
specimens.

Controls will be eligible for inclusion if

- They have been diagnosed with a first primary lung cancer, and

- They speak English or a language for which we have a translated consent form, and

- They understand and agree to sign informed consent, and

- They agree to give us a blood sample, and

- They agree to give us a tissue sample when part of normal clinical procedures, and

- They agree to complete the study questionnaires,

- They agree to have their pathology information reviewed. This will could include
biopsy specimens.

Exclusion Criteria:

- Subjects who do not meet the inclusion criteria as either cases or controls will not
be eligible for this study.

- Control subjects who have a history of another cancer, other than nonmelanoma skin
cancer or a first primary lung cancer, will not be eligible for this study.

- Control subjects who otherwise meet the eligibility requirements above but who have
had chemotherapy and/or are currently being treated with chemotherapy will be
excluded from the functional assay, but not from the genotyping.

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To conduct a pilot study of the role of DNA repair in lung cancer subjects with high genetic risk - those with a second primary lung cancer - compared to subjects with only one lung cancer.

Outcome Time Frame:

conclusion of the study

Safety Issue:

No

Principal Investigator

Irene Orlow, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

03-003

NCT ID:

NCT00611598

Start Date:

February 2003

Completion Date:

September 2013

Related Keywords:

  • Lung Cancer
  • Single Primary Lung Cancer
  • Second Primary Lung Cancer
  • Disease Susceptibility
  • Lung Neoplasms

Name

Location

Memorial Sloan Kettering Cancer CenterNew York, New York  10021