Inclusion Criteria:

- Patients who did not respond or are refractory to available therapy or for whom no
standard effective systemic therapy exists.

- Karnofsky performance status (KPS) ≥ 70%, or Eastern Cooperative Oncology Group
(ECOG) performance status 0 to 1

- Patients with adequate organ function

Exclusion Criteria:

- Anti-cancer chemotherapy, hormonal therapy, radiotherapy, immunotherapy, or
investigational agents within 4 weeks prior to the first dose of ARQ 197

- Known symptomatic brain metastases

- Pregnant or breastfeeding

- Uncontrolled intercurrent illness