SPECT Lymph Node Mapping to Define Nodal Clinical Target Volume in Patients With Prostate Cancer
Single photon emission computed tomography (SPECT) uses radioactive tracers and a scanner to
record data that a computer constructs into two- or three-dimensional images. A small amount
of a radioactive drug is injected into the body and a scanner is used to make detailed
images of areas inside the body where the radioactive material is taken up by the cells.
Using a gamma camera (a special kind of scanner), we can create a better picture of the
lymph node region. We will compare these pictures to images from your CT scan, to help plan
The research in this study involves seeing if it is feasible to use SPECT scanning
procedures for the purpose of planning your radiation treatment. We hope that doing so will
allow us to more accurately and precisely plan radiation treatment to potential sites of
cancer, and avoid delivering too much radiation to normal
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Determine the feasibility of using SPECT-LM
Safety: The study will be feasible if no more than 80% of patients experience the following complications: infection requiring hospitalization or IV antibiotics, urinary retention requiring placement of a Foley catheter, moderate or severe allergic reaction to Tc99. Efficacy: The study will be feasible if at least 80% of patients have at least one identifiable lymph node on SPECT-LM.
Completion of enrollment of all patients
Jeff Michalski, M.D.
Washington University School of Medicine
United States: Institutional Review Board
|Washington University School of Medicine||Saint Louis, Missouri 63110|