A Feasibility Study of Adaptive Intensity-Modulated Radiation Therapy in the Definitive Treatment of Head-and-Neck Cancer
In this study, we will plan additional measurements of the position of the patient's organs
weekly during radiation treatment. We will analyze these measurements in order to evaluate
whether we need to adjust our treatment procedures for the remainder of the treatments. We
might adjust the dose of radiation received to specific organs in order to try to minimize
the amount of radiation the healthy tissue receives.
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Feasibility of adaptive radiation therapy in the definitive treatment (MLC-based IMRT or helical tomotherapy)
Feasibility is determined by employing weekly 3D onboard imaging for plan re-evaluation and initiation of an adaptive process if the original PTV and/or normal structure goals are compromised.
Wade Thorstad, MD
Washington University School of Medicine
United States: Institutional Review Board
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