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Bone Marrow Derived Adult Liver Stem Cell Recruitment After Major Liver Resections: Correlation With Liver Regeneration and Hepatic Function


N/A
18 Years
N/A
Not Enrolling
Both
Liver Cancer

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Trial Information

Bone Marrow Derived Adult Liver Stem Cell Recruitment After Major Liver Resections: Correlation With Liver Regeneration and Hepatic Function


Inclusion Criteria:



- Adults (≥ or equal to 18 years old).

- Patients scheduled for resection of 3 or more liver segments for any indication, with
or without other planned procedures.

Or

- Normal healthy volunteers (control).

Exclusion Criteria:

- Chemotherapy or GCSF treatment in the preceding 4 weeks.

- CHILD'S classification B or above.

- Presence of active infection.

- History of lymphoma or leukemia.

- Normal healthy volunteers who underwent chemotherapy treatment at any stage of their
life will be excluded.

- Normal healthy volunteers who are under any active treatment for any active illness
will be excluded.

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

To determine qualitatively and quantitatively whether bone marrow derived liver associated stem cells are mobilized from the bone marrow in patients undergoing major liver resections (3 or more liver segments).

Outcome Time Frame:

conclusion of study

Safety Issue:

No

Principal Investigator

Ronald DeMatteo, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

06-017

NCT ID:

NCT00605800

Start Date:

March 2006

Completion Date:

March 2009

Related Keywords:

  • Liver Cancer
  • Liver resection
  • Liver Neoplasms

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