Anti-Inflammation & Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker
30 Years
60 Years
Male
Atherosclerosis, Smoking, Inflammation
Trial Information
Anti-Inflammation & Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker
Dextromethorphan (DM), an ingredient widely used in antitussive remedies, had been reported
to reduce the inflammation-mediated degeneration of neurons. We recently found that DM can
prevent vascular remodeling and neuron injury in animal models of carotid ligation and
cerebral ischemia injuries, respectively. It was believed that its action was through the
anti-oxidant and NADPH pathway to protect brain cells. However, the mechanism and actual
effect on human vascular protection remained unclear.
To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular
protection effect on heavy smokers, this prospective study will be conducted to treat
subjects with heavy smoking history with DM or not and evaluate the anti-inflammatory and
the improvement of endothelial function.
Inclusion Criteria:
- healthy male volunteers who are currently smoking
Exclusion Criteria:
- personal history of hypertension or diabetes mellitus
- family history with
- documented premature cardiovascular events
- cardiovascular-associated sudden death
- total cholesterol > 240 mg/dL
- triglyceride > 200 mg/dL
- low-density lipoprotein > 160 mg/dL.
Type of Study:
Interventional
Study Design:
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
Outcome Measure:
Endothelial function
Outcome Time Frame:
1, 2, 3 and 6 month
Safety Issue:
No
Principal Investigator
Ping-Yen Liu, MD, PhD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Assiatant Professor of National Cheng Kung University Medical Center
Authority:
Taiwan: Institutional Review Board
Study ID:
HR-93-28
NCT ID:
NCT00605605
Start Date:
March 2005
Completion Date:
December 2005
Related Keywords:
- Atherosclerosis
- Smoking
- Inflammation
- endothelial function
- atherosclerosis
- smoking
- inflammation
- antioxidant
- Atherosclerosis
- Inflammation
- Smoking
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