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Anti-Inflammation & Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker

Phase 4
30 Years
60 Years
Not Enrolling
Atherosclerosis, Smoking, Inflammation

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Trial Information

Anti-Inflammation & Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker

Dextromethorphan (DM), an ingredient widely used in antitussive remedies, had been reported
to reduce the inflammation-mediated degeneration of neurons. We recently found that DM can
prevent vascular remodeling and neuron injury in animal models of carotid ligation and
cerebral ischemia injuries, respectively. It was believed that its action was through the
anti-oxidant and NADPH pathway to protect brain cells. However, the mechanism and actual
effect on human vascular protection remained unclear.

To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular
protection effect on heavy smokers, this prospective study will be conducted to treat
subjects with heavy smoking history with DM or not and evaluate the anti-inflammatory and
the improvement of endothelial function.

Inclusion Criteria:

- healthy male volunteers who are currently smoking

Exclusion Criteria:

- personal history of hypertension or diabetes mellitus

- family history with

- documented premature cardiovascular events

- cardiovascular-associated sudden death

- total cholesterol > 240 mg/dL

- triglyceride > 200 mg/dL

- low-density lipoprotein > 160 mg/dL.

Type of Study:


Study Design:

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Outcome Measure:

Endothelial function

Outcome Time Frame:

1, 2, 3 and 6 month

Safety Issue:


Principal Investigator

Ping-Yen Liu, MD, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Assiatant Professor of National Cheng Kung University Medical Center


Taiwan: Institutional Review Board

Study ID:




Start Date:

March 2005

Completion Date:

December 2005

Related Keywords:

  • Atherosclerosis
  • Smoking
  • Inflammation
  • endothelial function
  • atherosclerosis
  • smoking
  • inflammation
  • antioxidant
  • Atherosclerosis
  • Inflammation
  • Smoking