Anti-Inflammation & Vascular Endothelial Protection Effects of Dextromethorphan on Heavy Smoker
Dextromethorphan (DM), an ingredient widely used in antitussive remedies, had been reported
to reduce the inflammation-mediated degeneration of neurons. We recently found that DM can
prevent vascular remodeling and neuron injury in animal models of carotid ligation and
cerebral ischemia injuries, respectively. It was believed that its action was through the
anti-oxidant and NADPH pathway to protect brain cells. However, the mechanism and actual
effect on human vascular protection remained unclear.
To test the hypothesis that DM could have anti-inflammatory effect and thus achieve vascular
protection effect on heavy smokers, this prospective study will be conducted to treat
subjects with heavy smoking history with DM or not and evaluate the anti-inflammatory and
the improvement of endothelial function.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
1, 2, 3 and 6 month
Ping-Yen Liu, MD, PhD
Assiatant Professor of National Cheng Kung University Medical Center
Taiwan: Institutional Review Board