Inclusion Criteria:

- Male or female patients, >18 years of age, who are able to understand and give
written informed consent.

- Histologically or cytologically confirmed pancreatic adenocarcinoma.

- Stage III (locally advanced, unresectable) or Stage IV (metastatic) disease,
including patients who underwent surgery but had incomplete resections.

- Treatment naïve (no prior chemotherapy, radiotherapy or investigational agents for
pancreatic cancer)

- Karnofsky performance status > 70 % (Appendix A).

- Expected survival > 3 months.

- At least 4 weeks beyond major surgery and recovered from all acute toxicities

- At least 2 weeks beyond corticosteroids, except low doses (i.e., 20 mg/day of
prednisone or equivalent) to treat nausea or other illness such as rheumatoid
arthritis

- Adequate hematology without ongoing transfusional support (hemoglobin > 11 g/dL, ANC
> 2,000 per mm3, platelets > 150,000 per mm3)

- Adequate renal and hepatic function (creatinine and bilirubin ≤ 1.5 X IULN, AST and
ALT ≤ 2.0 X IULN)

- Otherwise, all toxicity at study entry
Exclusion Criteria:

- Women who are pregnant or lactating.

- Women of childbearing potential and fertile men unwilling to use effective
contraception during study until conclusion of 12-week post-treatment evaluation
period.

- Known metastatic disease to the central nervous system.

- Presence of bulky disease (defined as any single mass >10 cm in its greatest
dimension)

- Patients with >Grade 2 anorexia, nausea or vomiting, and/or signs of intestinal
obstruction.

- Prior radiation dose >3,000 cGy to the liver, >2,000 cGy to lungs and kidneys or
prior external beam irradiation to a field that includes more than 30% of the
red marrow.

- Patients with non-melanoma skin cancer or carcinoma in situ of the cervix are
not excluded, but patients with other prior malignancies must have had at least
a 5-year disease free interval.

- Patients known to be HIV positive, hepatitis B positive, or hepatitis C
positive.

- Known history of active coronary artery disease, unstable angina, myocardial
infarction, or congestive heart failure present within 6 months or cardiac
arrhythmia requiring anti-arrhythmia therapy.

- Known history of active COPD, or other moderate-to-severe respiratory illness
present within 6 months.

- Known autoimmune disease or presence of autoimmune phenomena (except rheumatoid
arthritis requiring only low dose maintenance corticosteroids).

- Infection requiring intravenous antibiotic use within 1 week.

- Other concurrent medical or psychiatric conditions that, in the Investigator's
opinion, may be likely to confound study interpretation or prevent completion of
study procedures and follow-up examinations.