Genetic Analysis of Toxicity Associated With High-Dose Melphalan
- To determine whether single nucleotide polymorphisms (SNPs) in genes that encode the
melphalan transporters are associated with the development and/or severity of mucositis
in patients with multiple myeloma receiving high-dose melphalan.
- To determine whether SNPs in genes that influence melphalan metabolism are associated
with the development and/or severity of mucositis in these patients.
OUTLINE: This is a multicenter study.
Blood or mouthwash samples are collected and DNA isolated from these specimens is analyzed
for single nucleotide polymorphisms (SNPs) in LAT1 or other candidate genes. Public
databases (i.e., dbSNP and HapMap) are reviewed to select representative SNPs for genotype
Observational Model: Cohort, Time Perspective: Prospective
Association between single nucleotide polymorphisms (SNPs) in genes that encode the melphalan transporters and development and/or severity of mucositis
Stephen Brandt, MD
Vanderbilt-Ingram Cancer Center
United States: Federal Government
VICC HEM 0750
|Vanderbilt-Ingram Cancer Center||Nashville, Tennessee 37232-6838|
|Veterans Affairs Medical Center - Nashville||Nashville, Tennessee 37212|
|Vanderbilt-Ingram Cancer Center at Franklin||Nashville, Tennessee 37064|