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Genetic Analysis of Toxicity Associated With High-Dose Melphalan


N/A
18 Years
N/A
Not Enrolling
Both
Mucositis, Multiple Myeloma and Plasma Cell Neoplasm

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Trial Information

Genetic Analysis of Toxicity Associated With High-Dose Melphalan


OBJECTIVES:

- To determine whether single nucleotide polymorphisms (SNPs) in genes that encode the
melphalan transporters are associated with the development and/or severity of mucositis
in patients with multiple myeloma receiving high-dose melphalan.

- To determine whether SNPs in genes that influence melphalan metabolism are associated
with the development and/or severity of mucositis in these patients.

OUTLINE: This is a multicenter study.

Blood or mouthwash samples are collected and DNA isolated from these specimens is analyzed
for single nucleotide polymorphisms (SNPs) in LAT1 or other candidate genes. Public
databases (i.e., dbSNP and HapMap) are reviewed to select representative SNPs for genotype
analysis.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of multiple myeloma

- Receiving treatment with high-dose melphalan for an autologous stem cell
transplantation at any of these facilities:

- Vanderbilt University Medical Center

- Nashville Veteran's Administration Medical Center (VAMC)

- Seattle VAMC

- San Antonio VAMC

PATIENT CHARACTERISTICS:

- Not pregnant

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- No palifermin

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

Association between single nucleotide polymorphisms (SNPs) in genes that encode the melphalan transporters and development and/or severity of mucositis

Outcome Time Frame:

4 weeks

Safety Issue:

No

Principal Investigator

Stephen Brandt, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Vanderbilt-Ingram Cancer Center

Authority:

United States: Federal Government

Study ID:

VICC HEM 0750

NCT ID:

NCT00602147

Start Date:

July 2007

Completion Date:

April 2010

Related Keywords:

  • Mucositis
  • Multiple Myeloma and Plasma Cell Neoplasm
  • mucositis
  • stage I multiple myeloma
  • stage II multiple myeloma
  • stage III multiple myeloma
  • refractory multiple myeloma
  • Neoplasms
  • Multiple Myeloma
  • Neoplasms, Plasma Cell
  • Plasmacytoma
  • Mucositis

Name

Location
Vanderbilt-Ingram Cancer Center Nashville, Tennessee  37232-6838
Veterans Affairs Medical Center - Nashville Nashville, Tennessee  37212
Vanderbilt-Ingram Cancer Center at Franklin Nashville, Tennessee  37064