Quality of Life Among Long-Term Survivors of Resected Gastric Cancer
The purpose of this study is to measure the quality of life (QOL) of long-term survivors of
resected gastric cancer. This cohort of long-term survivors will include patients who have
no evidence of disease (NED) at least three years after having curative resection for
gastric cancer. There are three main types of surgical procedures used to resect primary
gastric cancer, which include proximal subtotal, distal subtotal, and total gastrectomy.
Surgical management of gastric cancer at Memorial Sloan-Kettering Cancer Center (MSKCC) has
shifted over the years to a greater use of proximal subtotal gastrectomies than in the past;
however the effects on the QOL of these patients are unknown. In this study, we propose to
use the European Organization for Research Treatment of Cancer (EORTC) two-part
questionnaire QLQ-C30 and QLQ-STO22. This instrument has been shown to be a valid and
reliable QOL instrument used to assess the quality of life of patients with gastric cancer.
We will measure multiple domains of QOL including, physical, role, cognitive, and emotional
functions. An additional 10-item questionnaire (MSK-10) was designed by GMT service surgeons
and will be administered in order to more specifically identify certain potential issues of
QOL among gastric cancer survivors. These issues include eating capabilities, work status
and major life changing events. Patients will be identified using the Gastric and Mixed
Tumor (GMT) Service Gastric Cancer Database. The questionnaires will be conducted via
telephone interview. Establishing these QOL measurements will help to provide valuable
baseline data upon which to base future clinical trials of optimal surgical techniques.
OBJECTIVES AND SCIENTIFIC AIMS
- To establish health related QOL using the EORTC QLQ-C30 and QLQ-STO22 in gastric cancer
patients who are alive and free of disease for three or more years after a proximal,
distal, or total gastrectomy for gastric cancer.
- To compare the differences in QOL scores between the three different types of
- To compare results using the EORTC QLQ-C30 with published norms established in the
- To use the MSK-10 to assess the incidence and degree of certain areas of QOL that may
affect gastric cancer survivors specifically.
Observational Model: Cohort, Time Perspective: Prospective
Instrument: EORTC QLQ-C30, QLQ-STO22, and MSK-10. The intent of this study is to assess QOL in long-term survivors of all surgical procedures performed for the treatment of gastric cancer.
Daniel Coit, MD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
|Memorial Sloan Kettering Cancer Center||New York, New York 10021|