Avastin and Chemotherapy Followed by Avastin Alone or in Combination With Tarceva for the Treatment of Metastatic Colorectal Cancer.
Patients with metastatic colorectal cancer will be treated with standard chemotherapy
according to the investigators choice. In addition to chemotherapy, Avastin (bevacizumab)
will be given during the treatment period. After the chemotherapy is finished (after 18
weeks), maintenance therapy will be given and the patients will be randomized to treatment
with either with Avastin alone or Avastin in combination with Tarceva (erlotinib). Patients
with progressive disease, or patients suitable to curative resection of metastases will be
taken out of study.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Anders Johnsson, MD PhD
Lund University Hospital Sweden
Sweden: Medical Products Agency