Avastin and Chemotherapy Followed by Avastin Alone or in Combination With Tarceva for the Treatment of Metastatic Colorectal Cancer.
Patients with metastatic colorectal cancer will be treated with standard chemotherapy
according to the investigators choice. In addition to chemotherapy, Avastin (bevacizumab)
will be given during the treatment period. After the chemotherapy is finished (after 18
weeks), maintenance therapy will be given and the patients will be randomized to treatment
with either with Avastin alone or Avastin in combination with Tarceva (erlotinib). Patients
with progressive disease, or patients suitable to curative resection of metastases will be
taken out of study.
Interventional
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
progression-free survival
3 years
Yes
Anders Johnsson, MD PhD
Principal Investigator
Lund University Hospital Sweden
Sweden: Medical Products Agency
ML19033
NCT00598156
June 2007
August 2012
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