The Use of Breathing Synchronized PET/CT Imaging In the Detection and Quantification of FDG Uptake in Lung Nodules
Positron emission tomography is now a clinically accepted imaging modality for the
evaluation of pulmonary nodules as well as for the staging of patients with lung cancer. PET
imaging with the radiotracer 18 Fluoro-deoxy-glucose (FDG) has a high accuracy for the
differentiation between benign and malignant lung lesions and for the detection of nodal
metastases. This is because malignant tumors are characterized by an increase in glucose
metabolism as compared to most normal tissues. In clinical practice, PET images are
interpreted visually or semiquantitatively, using a standardized uptake value (SUV).
Previous studies have shown that SUV thresholds can be used with high accuracy to
distinguish between benign and malignant lesions that exhibit increased uptake of FDG. In
addition, the SUV is frequently used as a surrogate marker for the evaluation of a response
to chemo- or radiation therapy. Unfortunately, the accuracy of SUV measurements may be
affected by lesion motion during the image acquisition. This is a particular problem in PET
imaging of the lung. Normal respiratory motion, and hence lesion motion, causes a smearing
effect, whereby the concentration of radiotracer within a given lesion is spread out over a
larger area. For the same reason small lesions and lesions with relatively low uptake of
radiotracer may become undetectable during normal breathing (partial volume effect). PET
images are acquired for several minutes, image acquisition during breath hold is therefore
not an option for clinical scans. However recently published work from UCLA (Auerbach et al.
J Nucl Med., February 2006) shows that 3 lesions per patient on average can be missed on
shallow breathing scans compared to breath-hold CT scans. These lesions did not show any FDG
uptake on clinical PET scans. The goal of this pilot study is to evaluate whether
respiratory gating during PET image acquisition enables the detection of those lesions which
are identified during the breath-hold CT scan.
Interventional
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Pts w/suspected lung lesions will undergo more breath-hold CT scan & if visible lesion(s), gated-PET will be acquired plus clinical PET/CT. Scans will be used to compare how often additional lung lesions can be identified on breath-hold CT, if lesions
5 years
No
Heiko Schoder, MD
Principal Investigator
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
04-025
NCT00598065
March 2004
December 2009
Name | Location |
---|---|
Memorial Sloan Kettering Cancer Center | New York, New York 10021 |