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Genetic Susceptibility to Lung Cancer in Never Smokers


N/A
N/A
N/A
Open (Enrolling)
Both
Lung Cancer

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Trial Information

Genetic Susceptibility to Lung Cancer in Never Smokers


Inclusion Criteria:



- Cases will be eligible for inclusion if:

- They have been diagnosed with a lung cancer or have had previous surgical treatment
for their lung cancer and have smoked fewer than 100 cigarettes in their lifetime,
are/were not regular cigar or pipe smokers, and

- They have had no prior chemotherapy or radiation treatment within the last year
(Exception: genotyping analysis/screening can be performed on specimens from
individuals who had chemo/radiation treatment within the last year as germline DNA
will not be affected)

- They speak and read English

- They understand and agree to sign informed consent, and

- They agree to give us a blood sample, and

- They agree to complete the study questionnaire, and

- They agree to have their pathology information reviewed by study personnel.

- Controls will be eligible for inclusion if:

- They have not been diagnosed with any type of cancer, exclusive of nonmelanoma skin
cancer and have smoked fewer than 100 cigarettes in their lifetime, are/were not
regular cigar or pipe smokers, and

- They speak and read English

- They understand and agree to sign informed consent, and

- They agree to give us a blood sample, and

- They agree to complete the study questionnaire.

Exclusion Criteria:

- Subjects who do not meet the inclusion criteria for either the case or control groups
will not be eligible for this study.

- All individuals who otherwise meet the eligibility requirements above, but who have
had chemotherapy or radiation therapy within 1 year of evaluation will be excluded
(Exception: genotyping analysis/screening can be performed on specimens from
individuals who had chemo/radiation treatment within the last year as germline DNA
will not be affected).

Type of Study:

Observational

Study Design:

Observational Model: Case Control, Time Perspective: Prospective

Outcome Measure:

To evaluate germline genetic variants and their association with lung cancer in never smokers.

Outcome Time Frame:

conclusion of study

Safety Issue:

No

Principal Investigator

Irene Orlow, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center

Authority:

United States: Institutional Review Board

Study ID:

05-038

NCT ID:

NCT00597636

Start Date:

June 2005

Completion Date:

June 2013

Related Keywords:

  • Lung Cancer
  • smokers
  • Disease Susceptibility
  • Lung Neoplasms

Name

Location

Memorial Sloan-Kettering Cancer CenterNew York, New York  10021