Quadrant High Dose Rate Intraoperative Radiation Therapy (IORT) for Early-Stage Breast Cancer: A Pilot Study
This pilot trial will evaluate the feasibility of intra operative radiation therapy (IORT)
given in one fraction at the time of wide local excision as the only adjuvant radiation
treatment in a group of patients with early-stage invasive breast cancer.
This study will enroll 60 women, older than 60 years of age, with breast cancer not more
than 2 cm in size and without evident additional tumoral foci around the tumor or in other
areas of the breast. An MSK radiologist will review your mammography to be sure you qualify
for this study. You may be asked to undergo additional mammography or other examinations,
such as breast ultrasound in order to verify that the tumor is located in a single quadrant
of the breast. Some of these procedures are routinely performed in all candidates for
conservative breast surgery.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
To determine tissue tolerance of the breast to a single intraoperative course of radiation.
Beryl McCormick, MD
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|