Trial Information

Vascular CT Assessment of Structural Autograft and Allograft Healing

The purpose of this study is to investigate quantitative vascular cone beam CT(CBCT) in a
clinical pilot of patients that have received a structural allograft for bone cancer or a
vascularized structural autograft for bone cancer or traumatic injury. Development of a
minimally invasive, longitudinal outcome measure to quantify intramedullary vascular volume
and cortical bone volume of structural allografts in patients is required to translate
"revitalizing" structural allograft in clinical trials. Our novel vascular CBCT will be
able to demonstrate the significant differences between vascularized fibular autografts vs.
structural allografts in patients that will undergo structural grafting. These data will be
used to devise a power calculation for a definitive clinical trial to evaluate the efficacy
of the revitalizing allograft.